MRI-guided biopsy and fine needle aspiration biopsy (FNAB) in the diagnosis of musculoskeletal lesions

Abstract Objectives The purpose of this study was to evaluate the diagnostic performance of magnetic resonance imaging (MRI) guided musculoskeletal biopsy and the value of fine needle aspiration biopsy (FNAB) when combined with histologic biopsy. Materials and methods A total of 172 biopsies were pe...

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Bibliographic Details
Published in:European journal of radiology 2013-12, Vol.82 (12), p.2328-2333
Main Authors: Kerimaa, Pekka, Marttila, Antti, Hyvönen, Pekka, Ojala, Risto, Lappi-Blanco, Elisa, Tervonen, Osmo, Blanco Sequeiros, Roberto
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biopsy
Biopsy, Fine-Needle
Bone Neoplasms - pathology
Child
Child, Preschool
Comorbidity
Female
Finland
Humans
Image-Guided Biopsy
Infant
Interventional MRI
Magnetic Resonance Imaging, Interventional
Male
Middle Aged
MRI guidance
Muscle Neoplasms - pathology
Musculoskeletal
Prevalence
Radiology
Reproducibility of Results
Sensitivity and Specificity
Tumor
Young Adult
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Summary:Abstract Objectives The purpose of this study was to evaluate the diagnostic performance of magnetic resonance imaging (MRI) guided musculoskeletal biopsy and the value of fine needle aspiration biopsy (FNAB) when combined with histologic biopsy. Materials and methods A total of 172 biopsies were performed under MRI guidance, 170 were histologic biopsies. In 112 cases, a fine needle aspiration biopsy was also performed. In two cases, a stand-alone FNAB was performed. The diagnostic performance was evaluated retrospectively by comparing the histopathologic and cytologic diagnosis with the current or final diagnosis after at least one year of clinical and imaging follow-up. A 0.23 T open MRI scanner with an interventional stereotactic guidance system was used. Results The overall diagnostic accuracy of MRI guided biopsy was 0.95, sensitivity 0.91, specificity 0.98, positive predictive value (ppv) 0.97 and negative predictive value (npv) 0.93. The diagnostic accuracy of trephine biopsy alone was 0.93, sensitivity 0.89, specificity 0.98, ppv 0.97 and npv 0.91 and accuracy for FNAB alone was 0.85, sensitivity 0.80, specificity 0.90, ppv 0.89 and npv 0.82. Conclusions MRI guidance is a feasible and accurate tool in percutaneous musculoskeletal biopsies. Fine needle biopsy is a useful low-cost supplement to histologic biopsy.
ISSN:0720-048X
1872-7727
DOI:10.1016/j.ejrad.2013.09.005