An epidemiological study of the association of coffee with chronic liver disease

Background and aims Chronic liver disease affects 855 people per million in the UK. Previous studies have reported that coffee appears protective against the development of abnormal liver enzymes, hepatic fibrosis and cirrhosis. The aim of this study, the first in a Scottish population, was to compa...

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Bibliographic Details
Published in:Scottish medical journal 2013-11, Vol.58 (4), p.217-222
Main Authors: Walton, HB, Masterton, GS, Hayes, PC
Format: Article
Language:English
Subjects:
Caffeine - administration & dosage
Caffeine - pharmacology
Case-Control Studies
Coffee
Diterpenes - administration & dosage
Diterpenes - pharmacology
End Stage Liver Disease - epidemiology
End Stage Liver Disease - pathology
End Stage Liver Disease - prevention & control
Female
Humans
Liver Cirrhosis - prevention & control
Logistic Models
Male
Middle Aged
Prevalence
Protective Agents - administration & dosage
Protective Agents - pharmacology
Reproducibility of Results
Scotland - epidemiology
Surveys and Questionnaires
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Summary:Background and aims Chronic liver disease affects 855 people per million in the UK. Previous studies have reported that coffee appears protective against the development of abnormal liver enzymes, hepatic fibrosis and cirrhosis. The aim of this study, the first in a Scottish population, was to compare coffee consumption in patients with liver disease and that of control populations to determine correlations between coffee intake and the incidence of non-cancerous liver disease and with Child’s-Pugh and model for end-stage liver disease (MELD) scores. Methods and results Two hundred and eighty-six patients attending the liver outpatient department at the Royal Infirmary of Edinburgh completed a questionnaire regarding coffee consumption and lifestyle factors. Control questionnaires were also completed by 100 orthopaedic outpatients and 120 medical students. Patients with cirrhosis (n = 95) drank significantly less coffee than those without cirrhosis (p = 
ISSN:0036-9330
2045-6441
DOI:10.1177/0036933013507869