Three-generation reproduction and dominant lethal mutagenesis studies of ethylene glycol in the rat

To assess the possible effects of ethylene glycol (EG) on reproductive performance and mutagenesis, three-generation reproduction and dominant lethal mutagenesis studies were performed in the Fischer 344 rat. EG was included in the diet at approximate dosages of 1.0, 0.2, and 0.04 g/kg/day during th...

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Bibliographic Details
Published in:Fundamental and applied toxicology 1986, Vol.7 (4), p.566-572
Main Authors: DePass, Linval R., Woodside, Murray D., Maronpot, Robert R., Weil, Carrol S.
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Biological and medical sciences
Body Weight - drug effects
Chemical mutagenesis
Ethylene Glycol
Ethylene Glycols - toxicity
Female
Fertility - drug effects
Genes, Dominant
Genes, Lethal
Male
Medical sciences
Mutagens
Mutation
Pregnancy
Rats
Rats, Inbred F344
Reproduction - drug effects
Toxicology
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Summary:To assess the possible effects of ethylene glycol (EG) on reproductive performance and mutagenesis, three-generation reproduction and dominant lethal mutagenesis studies were performed in the Fischer 344 rat. EG was included in the diet at approximate dosages of 1.0, 0.2, and 0.04 g/kg/day during three generations of reproduction. Each generation was bred once. In a dominant lethal mutagenesis study, the F2 males from the reproduction study were bred to three consecutive lots of untreated females at weekly intervals. Concomitantly, another group of untreated F2 males that received a single ip injection of 0.50 mg/kg triethylenemelamine (TEM) were bred similarly to serve as a positive control group. No evidence of reduced fertility or increased fetal death was observed in any of the groups receiving EG. Dominant lethal effects in the TEM group confirmed the susceptibility of the rats to a known mutagen. In conclusion, there were no reproductive or dominant lethal effects associated with the inclusion of as much as 1.0 g/kg/day of EG in the diet.
ISSN:0272-0590
1095-6832
DOI:10.1016/0272-0590(86)90106-5