Hemolytic uremic syndrome in a patient on cis-platinum, vinblastine and bleomycin

A 23-year-old woman with metastatic Sertoli-Leydig cell tumor was treated with cisplatin, vinblastine, and bleomycin. Hemolytic uremic syndrome appeared, while no evidence of residual tumor was found. Infusion of fresh frozen plasma together with aspirin and dipyridamole resulted in recovery of micr...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 1985-01, Vol.110 (2), p.119-122
Main Authors: VAN DER MEER, J, DE VRIES, E. G. E, VRIESENDORP, R, WILLEMSE, P. H. B, DONKER, A. J. M, AALDERS, J. G
Format: Article
Language:English
Subjects:
Adult
Anemia, Hemolytic - chemically induced
Anemia, Hemolytic - drug therapy
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Biological and medical sciences
Bleomycin - adverse effects
Cisplatin - adverse effects
Drug toxicity and drugs side effects treatment
Female
Humans
Leydig Cell Tumor - drug therapy
Medical sciences
Ovarian Neoplasms - drug therapy
Pelvic Neoplasms - secondary
Pharmacology. Drug treatments
Sertoli Cell Tumor - drug therapy
Syndrome
Toxicity: urogenital system
Uremia - chemically induced
Uremia - drug therapy
Vinblastine - adverse effects
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Summary:A 23-year-old woman with metastatic Sertoli-Leydig cell tumor was treated with cisplatin, vinblastine, and bleomycin. Hemolytic uremic syndrome appeared, while no evidence of residual tumor was found. Infusion of fresh frozen plasma together with aspirin and dipyridamole resulted in recovery of microangiopathic hemolytic anemia and thrombocytopenia. Renal insufficiency, however, persisted.
ISSN:0171-5216
1432-1335
DOI:10.1007/bf00402723