In vivo sister chromatid exchange and micronucleus induction studies with 1,3-butadiene in B6C3F sub(1) mice and Sprague-Dawley rats

Male B6C3F sub(1) mice and Sprague-Dawley rats were exposed for 2 days, 6h/day to 1,3-butadiene (BD) by inhalation and their bone marrow cells were evaluated for the induction of micronuclei (MN) and sister chromatid exchanges (SCEs). A significant dose-dependent increase in MN induction was observe...

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Bibliographic Details
Published in:Mutagenesis 1986-01, Vol.1 (6), p.449-452
Main Authors: Cunningham, MJ, Choy, W N, Theall Arce, G, Rickard, L B, Vlachos, DA, Kinney, LA, Sarrif, A M
Format: Article
Language:English
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Summary:Male B6C3F sub(1) mice and Sprague-Dawley rats were exposed for 2 days, 6h/day to 1,3-butadiene (BD) by inhalation and their bone marrow cells were evaluated for the induction of micronuclei (MN) and sister chromatid exchanges (SCEs). A significant dose-dependent increase in MN induction was observed in mice. At 100 p.p.m., the frequency of micronucleated polychromatic erythrocytes was 6-fold above control with a maximal induction of 38-fold at 10,000 p.p.m. A significant increase in SCEs was also observed in mouse bone marrow cells starting at 100 p.p.m. with a 4-fold increase over the control evident at 10,000 p.p.m. The highest tested no observed effect level for both endpoints was 50 p.p.m. In contrast, rat bone marrow cells did not exhibit significant increases in micronucleated polychromatic erythrocytes or SCEs.
ISSN:0267-8357