Effects of Oxidative Stress on the Erythrocyte Na super(+),K super(+) ATPase Activity in Female Hyperthyroid Patients

In 22 female hyperthyroid patients who were not receiving antithyroid therapy, the effects of free-radical-induced membrane damage induced by the condition were studied on the Na super(+),K super(+)-ATPase activity of erythrocyte membranes before and four weeks after therapy with propylthiouracil (P...

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Bibliographic Details
Published in:Journal of toxicology and environmental health. Part A 2001-06, Vol.63 (4), p.289-289
Main Authors: Konukoglu, Dildar, Yelke, Hakan Kadir, Hatemi, Husrev, Sabuncu, Tevfik
Format: Article
Language:English
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Summary:In 22 female hyperthyroid patients who were not receiving antithyroid therapy, the effects of free-radical-induced membrane damage induced by the condition were studied on the Na super(+),K super(+)-ATPase activity of erythrocyte membranes before and four weeks after therapy with propylthiouracil (PTU). Results revealed that, compared to controls, there was a significant rise in triiodothyronine and thyroxine levels accompanied by a fall in thyroid-stimulating hormone levels in the hyperthyroid patients, and increased lipid peroxidation was associated with a significant decrease in erythrocyte glutathione levels. The Na super(+),K super(+)-ATPase activity was also markedly lower in the hyperthyroid patients. Treatment with PTU significantly lowered triiodothyronine and thyroxine levels, but increased thyroid-stimulating hormone, ATPase, and Na super(+),K super(+)-ATPase activities, and elevated glutathione levels. Plasma thiobarbituric acid-reactive substances content was reduced after treatment with PTU.
ISSN:1528-7394