High contrast three-dimensional photoacoustic imaging through scattering media by localized optical fluence enhancement

We demonstrate enhanced three-dimensional photoacoustic imaging behind a scattering material by increasing the fluence in the ultrasound transducer focus. We enhance the optical intensity using wavefront shaping before the scatterer. The photoacoustic signal induced by an object placed behind the sc...

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Bibliographic Details
Published in:Optics express 2013-11, Vol.21 (22), p.26671-26676
Main Authors: Caravaca-Aguirre, Antonio M, Conkey, Donald B, Dove, Jacob D, Ju, Hengyi, Murray, Todd W, Piestun, Rafael
Format: Article
Language:English
Subjects:
Algorithms
Elasticity Imaging Techniques - instrumentation
Elasticity Imaging Techniques - methods
Equipment Design
Equipment Failure Analysis
Imaging, Three-Dimensional - instrumentation
Imaging, Three-Dimensional - methods
Photoacoustic Techniques - instrumentation
Photoacoustic Techniques - methods
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Summary:We demonstrate enhanced three-dimensional photoacoustic imaging behind a scattering material by increasing the fluence in the ultrasound transducer focus. We enhance the optical intensity using wavefront shaping before the scatterer. The photoacoustic signal induced by an object placed behind the scattering medium serves as feedback to optimize the wavefront, enabling one order of magnitude enhancement of the photoacoustic amplitude. Using the enhanced optical intensity, we scan the object in two-dimensions before post-processing of the data to reconstruct the image. The temporal profile of the photoacoustic signal provides the information used to reconstruct the third dimension.
ISSN:1094-4087
1094-4087
DOI:10.1364/OE.21.026671