Metabolic profile in women of different body mass indices with polycystic ovary syndrome

To characterize and compare clinical, anthropometric and biochemical-metabolic variables in patients with polycystic ovary syndrome (PCOS), stratified according to body mass index (BMI). A cross-sectional study conducted on 78 women aged 18 to 45 years with a clinical diagnosis of PCOS by the Rotter...

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Published in:Revista Brasileira de ginecologia e obstetrícia 2013-09, Vol.35 (9), p.413-420
Main Authors: de Sousa, Rosângela Maria Lopes, Chein, Maria Bethânia da Costa, da Silva, Diego Salvador Muniz, Dutra, Maysa Baldez, Navarro, Paula Andrea de Albuquerque Salles, de Figueiredo Neto, José Albuquerque, Brito, Luciane Maria Oliveira
Format: Article
Language:Portuguese
Subjects:
Adolescent
Adult
Body Mass Index
Cross-Sectional Studies
Female
Humans
Metabolome
Polycystic Ovary Syndrome - metabolism
Young Adult
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Summary:To characterize and compare clinical, anthropometric and biochemical-metabolic variables in patients with polycystic ovary syndrome (PCOS), stratified according to body mass index (BMI). A cross-sectional study conducted on 78 women aged 18 to 45 years with a clinical diagnosis of PCOS by the Rotterdam criteria. Patients were stratified according to BMI. The variables analyzed were: age, marital status, physical inactivity, menstrual irregularity, blood pressure (BP), anthropometric measurements, lipid profile, fasting glucose, and hormone measurements. To compare the variables between the different BMI values we used analysis of variance and the Kruskal-Wallis test. The level of significance was set at 5% for all tests. The patients had a mean age of 26.3 years, 79.5% of them were sedentary and 68% had hyperandrogenism. Waist circumference, waist/hip ratio, waist/height ratio and percentage of body fat were higher in the obese group. The markers of cardiovascular risk (CVR - fasting glucose, systolic and diastolic BP and LDL-cholesterol) were directly proportional to BMI, whereas HDL-cholesterol and SHBG were inversely related to BMI. The presence of markers of CVR factors increased proportionally to BMI, indicating that the metabolic profile of obese women with PCOS is more unfavorable than that of non-obese patients.
ISSN:1806-9339
DOI:10.1590/S0100-72032013000900006