Portable device for magnetic stimulation: assessment survival and proliferation in human lymphocytes

A device's instrumentation for magnetic stimulation on human lymphocytes is presented. This is a new procedure to stimulate growing cells with ferrofluid in vortices of magnetic field. The stimulation of magnetic vortices was provided at five different frequencies, from 100 to 2500 Hz and inten...

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Bibliographic Details
Published in:Review of scientific instruments 2013-09, Vol.84 (9), p.094701-094701
Main Authors: Pérez, H, Cordova-Fraga, T, López-Briones, S, Martínez-Espinosa, J C, Rosas, E F, Espinoza, A, Villagómez-Castro, J C, Sosa, M, Topsu, S, Bernal-Alvarado, J J
Format: Article
Language:English
Subjects:
Cell Proliferation
Cell Survival - drug effects
Cells, Cultured
Culture Media - pharmacology
Humans
Lymphocytes - cytology
Lymphocytes - metabolism
Magnetic Fields
Mitogens - pharmacology
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Summary:A device's instrumentation for magnetic stimulation on human lymphocytes is presented. This is a new procedure to stimulate growing cells with ferrofluid in vortices of magnetic field. The stimulation of magnetic vortices was provided at five different frequencies, from 100 to 2500 Hz and intensities from 1.13 to 4.13 mT. To improve the stimulation effects, a paramagnetic ferrofluid was added on the cell culture medium. The results suggest that the frequency changes and the magnetic field variation produce an important increase in the number of proliferating cells as well as in the cellular viability. This new magnetic stimulation modality could trigger an intracellular mechanism to induce cell proliferation and cellular survival only on mitogen stimulated cells.
ISSN:0034-6748
1089-7623
DOI:10.1063/1.4819796