Effects of Repeated Exposure of Rats to JP-5 Jet Fuel Vapor on Neurobehavioral Capacity and Neurotransmitter Levels

Male Sprague Dawley rats were exposed to jet-propulsion (JP)-5 or JP-8 vapor for 6 h/d, 5 d/week, for six consecutive weeks, and after a rest period of 65 d, the animals were evaluated for changes in performance capacity using a battery of neurobehavioral tests and for changes in concentrations of b...

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Bibliographic Details
Published in:Journal of toxicology and environmental health. Part A 2001-07, Vol.63 (6), p.397-397
Main Authors: Rossi, John, Nordholm, Alan F, Carpenter, Robert L, Ritchie, Glenn D, Malcomb, Willie
Format: Article
Language:English
Online Access:Get full text
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Summary:Male Sprague Dawley rats were exposed to jet-propulsion (JP)-5 or JP-8 vapor for 6 h/d, 5 d/week, for six consecutive weeks, and after a rest period of 65 d, the animals were evaluated for changes in performance capacity using a battery of neurobehavioral tests and for changes in concentrations of brain and blood serum neurotransmitters and metabolites. Animals were also exposed to high-efficiency particulate filtered/conditioned room air as controls. Each of the neurobehavioral tests used is described. Results showed that exposure to both fuels induced neurobehavioral deficits in the rats, although each exposure condition induced a unique pattern of neurobehavioral and transmitter modulations. The only significant difference in blood serum neurotransmitters between the two fuels was a significantly higher concentration of 5-hydroxyindoleacetic acid in serum of JP-5-exposed rats compared to controls and a significantly lower concentration in serum of JP-8-exposed animals compared to controls.
ISSN:1528-7394