The Effects of an Antiosteoporosis Herbal Formula Containing Epimedii Herba, Ligustri Lucidi Fructus and Psoraleae Fructus on Density and Structure of Rat Long Bones Under Tail-Suspension, and its Mechanisms of Action

An innovative anti‐osteoporosis herbal formula containing Epimedii Herba, Ligustri Lucidi Fructus and Psoraleae Fructus (ELP) has been previously shown its bone protecting effects in ovariectomized osteoporotic rats and also in post‐menopausal osteopenic women. This study aimed to investigate the ef...

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Published in:Phytotherapy research 2013-04, Vol.27 (4), p.484-492
Main Authors: Siu, Wing-Sum, Wong, Hing-Lok, Lau, Ching-Po, Shum, Wai-Ting, Wong, Chun-Wai, Gao, Si, Fung, Kwok-Pui, Lau, Clara Bik-San, Hung, Leung-Kim, Ko, Chun-Hay, Leung, Ping-Chung
Format: Article
Language:English
Subjects:
adipogenesis
Adipogenesis - drug effects
Animals
Bone Resorption - drug therapy
Bone Resorption - prevention & control
Cell Line
disuse osteoporosis
Drugs, Chinese Herbal - pharmacology
Epimedii Herba
Hindlimb Suspension
Ligustri Lucidi Fructus
Ligustrum - chemistry
Macrophages - drug effects
Male
mesenchymal stem cell
Mesenchymal Stromal Cells - drug effects
osteoclastogenesis
Osteoclasts - drug effects
osteogenesis
Osteogenesis - drug effects
Psoralea - chemistry
Psoraleae Fructus
Rats
Rats, Sprague-Dawley
tail-suspension
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Summary:An innovative anti‐osteoporosis herbal formula containing Epimedii Herba, Ligustri Lucidi Fructus and Psoraleae Fructus (ELP) has been previously shown its bone protecting effects in ovariectomized osteoporotic rats and also in post‐menopausal osteopenic women. This study aimed to investigate the efficacy of ELP against bone loss during physical inactivity or weightlessness. A hindlimb unloading tail‐suspended rat model was used for studying the effects of ELP on bone mineral density (BMD) and bone micro‐architecture. For in vitro mechanistic studies, rat mesenchymal stem cells (MSCs) and mouse macrophage cells (RAW264.7) were used for studying the effects of ELP on osteogenic/adipogenic differentiations and osteoclastogenesis, respectively. Our data illustrated that ELP had a significant preventive effect against bone loss induced by tail‐suspension (TS) at day 28 (p 
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.4743