Metal-organic frameworks for the storage and delivery of biologically active hydrogen sulfide

Hydrogen sulfide is an extremely toxic gas that is also of great interest for biological applications when delivered in the correct amount and at the desired rate. Here we show that the highly porous metal-organic frameworks with the CPO-27 structure can bind the hydrogen sulfide relatively strongly...

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Bibliographic Details
Published in:Dalton transactions : an international journal of inorganic chemistry 2012-04, Vol.41 (14), p.4060-4066
Main Authors: Allan, Phoebe K, Wheatley, Paul S, Aldous, David, Mohideen, M Infas, Tang, Chiu, Hriljac, Joseph A, Megson, Ian L, Chapman, Karena W, De Weireld, Guy, Vaesen, Sebastian, Morris, Russell E
Format: Article
Language:English
Subjects:
Animals
Coronary Vessels - drug effects
Coronary Vessels - physiology
Drug Carriers - administration & dosage
Drug Carriers - chemistry
Drug Stability
Hydrogen Sulfide - administration & dosage
Hydrogen Sulfide - chemistry
In Vitro Techniques
Powder Diffraction
Swine
Vasodilation - drug effects
X-Ray Diffraction
Zinc Compounds - administration & dosage
Zinc Compounds - chemistry
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Summary:Hydrogen sulfide is an extremely toxic gas that is also of great interest for biological applications when delivered in the correct amount and at the desired rate. Here we show that the highly porous metal-organic frameworks with the CPO-27 structure can bind the hydrogen sulfide relatively strongly, allowing the storage of the gas for at least several months. Delivered gas is biologically active in preliminary vasodilation studies of porcine arteries, and the structure of the hydrogen sulfide molecules inside the framework has been elucidated using a combination of powder X-ray diffraction and pair distribution function analysis.
ISSN:1477-9226
1477-9234
DOI:10.1039/c2dt12069k