Loading…

Changes in conjunctival cytology and tear function tests with radioiodine treatment for hyperthyroidism

Objectives Radioiodine (RAI) is used in the treatment of hyperthyroidism and differentiated thyroid cancer. Radioiodine therapy is associated with dry eyes and some side effects are seen especially due to beta rays. In this study, the functional and cytological status of lacrimal glands after RAI th...

Full description

Saved in:
Bibliographic Details
Published in:Annals of nuclear medicine 2013-10, Vol.27 (8), p.694-699
Main Authors: Koca, Gökhan, Acar, Ugur, Atilgan, Hasan Ikbal, Ergintürk Acar, Damla, Altiparmak, Ugur Emrah, Demirel, Koray, Yalniz-Akkaya, Zuleyha, Ustun, Huseyin, Korkmaz, Meliha, Ornek, Firdevs
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objectives Radioiodine (RAI) is used in the treatment of hyperthyroidism and differentiated thyroid cancer. Radioiodine therapy is associated with dry eyes and some side effects are seen especially due to beta rays. In this study, the functional and cytological status of lacrimal glands after RAI therapy was evaluated. Methods Twenty-five patients with a mean age of 55.16 years with planned low-dose RAI therapy were evaluated. Just before and 6 months after the treatment, the lacrimal glands were evaluated with tear break-up time (BUT), Schirmer’s test, impression cytology and “Ocular Surface Disease Index (OSDI)” questionnaire. Results The mean value of Schirmer’s test was 16.20 ± 3.61 pre-treatment and 11.28 ± 4.39 post-treatment for the right eye, and 15.76 ± 3.27 and 10.60 ± 4.42 for the left eye, respectively. The mean value of Schirmer’s test decreased significantly post-treatment in both eyes ( p  = 0.0001). The BUT score also decreased significantly post-treatment ( p  = 0.001). The mean value of OSDI score was 27.5 ± 8.02 pre-treatment and 46.36 ± 10.27 post-treatment. The mean value of OSDI score increased post-treatment ( p  = 0.0001). The impression scores also increased post-treatment in both eyes ( p  = 0.0001). Conclusion Even low-dose (≤30 mci) RAI treatment affects lacrimal gland functions. Low-dose RAI causes a decrease in the value of Schirmer’s test and the BUT test, and an increase in the value of OSDI score and impression scores.
ISSN:0914-7187
1864-6433
DOI:10.1007/s12149-013-0705-9