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Inhibition of protein synthesis or mTOR in the basolateral amygdala blocks retrieval-induced memory strengthening
Fear memory retrieval can lead to either reconsolidation (accompanied or not by strengthening of the memory trace) or extinction. Here, we show that non-reinforced retrieval of inhibitory avoidance (IA) conditioning can induce memory strengthening assessed in a subsequent retention test trial. Infus...
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| Published in: | Journal of Neural Transmission 2013-11, Vol.120 (11), p.1525-1531 |
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| Main Authors: | , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c471t-ed05078433eb1ad8c9bd276c4ba3de3fed3ae14e569f90206cfb3b935dd5a1ce3 |
| container_end_page | 1531 |
| container_issue | 11 |
| container_start_page | 1525 |
| container_title | Journal of Neural Transmission |
| container_volume | 120 |
| creator | Pedroso, Thiago R. Jobim, Paulo F. C. Carvalho, Leonardo M. Christoff, Raissa R. Maurmann, Natasha Reolon, Gustavo K. Werenicz, Aline Roesler, Rafael |
| description | Fear memory retrieval can lead to either reconsolidation (accompanied or not by strengthening of the memory trace) or extinction. Here, we show that non-reinforced retrieval of inhibitory avoidance (IA) conditioning can induce memory strengthening assessed in a subsequent retention test trial. Infusion of the protein synthesis inhibitor cycloheximide or the mTOR inhibitor rapamycin into the rat basolateral complex of the amygdala (BLA) after a reactivation (retrieval) session impaired retrieval-induced strengthening. Intra-BLA infusion of the mRNA synthesis inhibitor 5,6-dichloro-1-beta-
d
-ribofuranosylbenzimidazole (DRB) after retrieval had no effect. These findings provide the first evidence suggesting that non-reinforced IA retrieval can lead to memory strengthening through a mechanism dependent on protein synthesis and mTOR activity in the BLA. |
| doi_str_mv | 10.1007/s00702-013-1032-y |
| format | article |
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d
-ribofuranosylbenzimidazole (DRB) after retrieval had no effect. These findings provide the first evidence suggesting that non-reinforced IA retrieval can lead to memory strengthening through a mechanism dependent on protein synthesis and mTOR activity in the BLA.</description><subject>Amygdala - drug effects</subject><subject>Amygdala - metabolism</subject><subject>Animals</subject><subject>Avoidance Learning - drug effects</subject><subject>Avoidance Learning - physiology</subject><subject>Conditioning, Classical - drug effects</subject><subject>Conditioning, Classical - physiology</subject><subject>Cycloheximide - pharmacology</subject><subject>Extinction, Psychological - drug effects</subject><subject>Extinction, Psychological - physiology</subject><subject>Fear - drug effects</subject><subject>Fear - physiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Memory - drug effects</subject><subject>Memory - physiology</subject><subject>Neurology</subject><subject>Neurosciences</subject><subject>Protein Biosynthesis - drug effects</subject><subject>Protein Synthesis Inhibitors - pharmacology</subject><subject>Psychiatry</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sirolimus - pharmacology</subject><subject>TOR Serine-Threonine Kinases - antagonists & inhibitors</subject><subject>Translational Neurosciences - Original Article</subject><issn>0300-9564</issn><issn>1435-1463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp1kUtLHjEUhkNpqZ-XH-CmBLrpJnoyydyWIq0KgiB2HXI58xk7k2gyU5h_38inUgQ3CZw875uEh5BjDiccoD3NZYGKAReMg6jY-olsuBQ147IRn8kGBADr60bukf2cHwCA87b7SvYq0cieV3JDnq7CvTd-9jHQONDHFGf0geY1zPeYfaYx0enu5paWYZlQo3Mc9YxJj1RP69bpUVMzRvsn04Rz8vhXj8wHt1h0dMIpppXmOWHYlnjwYXtIvgx6zHj0sh-Q379-3p1fsuubi6vzs2tmZctnhg5qaDspBBquXWd746q2sdJo4VAM6IRGLrFu-qGHCho7GGF6UTtXa25RHJAfu97yp6cF86wmny2Oow4Yl6y4rLtaNm0jC_r9HfoQlxTK6wolRd9BL7tC8R1lU8w54aAek590WhUH9exD7Xyo4kM9-1BryXx7aV7MhO4t8SqgANUOyOUobDH9d_WHrf8AHr2YXw</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Pedroso, Thiago R.</creator><creator>Jobim, Paulo F. 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d
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| ispartof | Journal of Neural Transmission, 2013-11, Vol.120 (11), p.1525-1531 |
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| language | eng |
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| source | Springer Nature |
| subjects | Amygdala - drug effects Amygdala - metabolism Animals Avoidance Learning - drug effects Avoidance Learning - physiology Conditioning, Classical - drug effects Conditioning, Classical - physiology Cycloheximide - pharmacology Extinction, Psychological - drug effects Extinction, Psychological - physiology Fear - drug effects Fear - physiology Male Medicine Medicine & Public Health Memory - drug effects Memory - physiology Neurology Neurosciences Protein Biosynthesis - drug effects Protein Synthesis Inhibitors - pharmacology Psychiatry Rats Rats, Wistar Sirolimus - pharmacology TOR Serine-Threonine Kinases - antagonists & inhibitors Translational Neurosciences - Original Article |
| title | Inhibition of protein synthesis or mTOR in the basolateral amygdala blocks retrieval-induced memory strengthening |
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