Humoral and Cellular Immunity in Chromium Picolinate-Supplemented Lambs

The effects of oral supplementation of chromium picolinate (CrPic) on humoral and cellular immunity in sheep were investigated. Twenty-four male lambs divided into four treatments and received different dosages of CrPic: placebo (0), 0.250, 0.375, and 0.500 mg of chromium/animal/day during 84 days....

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Bibliographic Details
Published in:Biological trace element research 2013-08, Vol.154 (2), p.196-201
Main Authors: Dallago, B. S. L, McManus, C. M, Caldeira, D. F, Campeche, A, Burtet, R. T, Paim, T. P, Gomes, E. F, Branquinho, R. P, Braz, S. V, Louvandini, H
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biomedical and Life Sciences
Biomedical research
Biotechnology
blood serum
cell-mediated immunity
chickens
Chromium
Dietary minerals
Dietary Supplements
enzyme-linked immunosorbent assay
hay
humoral immunity
Hypersensitivity
Hypersensitivity, Delayed - blood
Hypersensitivity, Delayed - immunology
Immune response
Immune system
Immunity (Disease)
Immunity, Cellular - drug effects
Immunity, Humoral - drug effects
immunoglobulin G
Immunoglobulin G - blood
Immunoglobulin G - immunology
Iron Chelating Agents - pharmacology
lambs
Life Sciences
Male
Nutrition
Oncology
ovalbumin
Panicum maximum
phytohemagglutinin
Picolinic Acids - pharmacology
Sheep
toxicity
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Summary:The effects of oral supplementation of chromium picolinate (CrPic) on humoral and cellular immunity in sheep were investigated. Twenty-four male lambs divided into four treatments and received different dosages of CrPic: placebo (0), 0.250, 0.375, and 0.500 mg of chromium/animal/day during 84 days. The base ration was Panicum maximum cv Massai hay and concentrate. Blood samples were collected fortnightly for total and differential leukocyte counts. On days 28 and 56, the lambs were challenged with chicken ovalbumin I.M. Serum samples were collected on days 46 and 74 and subjected to an indirect enzyme-linked immunosorbent assay to measure IgG anti-ovalbumin. The cell-mediated immune response was determined by a delay-type hypersensitivity test using phytohemagglutinin. CrPic did not significantly affect humoral immunity in lambs but there was a negative effect on cellular immunity (P 
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-013-9731-7