A method of increasing the sensitivity for laser desorption in an ion trap mass spectrometer

Laser desorption in an ion trap mass spectrometer shows significant promise for both qualitative and trace analysis. In this work, we explore various combinations of time-varying DC and radiofrequency (RF) fields in order to optimize laser-generated signals. By judicious choice of timing between the...

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Bibliographic Details
Published in:Journal of the American Society for Mass Spectrometry 1993-09, Vol.4 (9), p.706-709
Main Authors: Eiden, G.C., Cisper, M.E., Alexander, M.L., Hemberger, P.H., Nogar, N.S.
Format: Article
Language:English
Subjects:
Exact sciences and technology
Instruments, apparatus, components and techniques common to several branches of physics and astronomy
Mass spectrometers and related techniques
Physics
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Summary:Laser desorption in an ion trap mass spectrometer shows significant promise for both qualitative and trace analysis. In this work, we explore various combinations of time-varying DC and radiofrequency (RF) fields in order to optimize laser-generated signals. By judicious choice of timing between the laser desorption pulse and the rise in the applied RF trapping potential, we observed over an order of magnitude enhancement in the trapped ion signal. This new method for laser desorption has enabled us to observe mass spectra of many compounds (e.g., pyrene, dichlorobenzene, and ferrocene) that are barely detectable using previous laser desorption methods. Effects of laser timing and the magnitude of the steady-state RF potential are discussed.
ISSN:1044-0305
1879-1123
DOI:10.1016/1044-0305(93)80048-4