Glutamate-induced epigenetic and morphological changes allow rat Müller cell dedifferentiation but not further acquisition of a photoreceptor phenotype

Highlights • Glutamate triggers a rapid dedifferentiation response in rat Müller mature cells. • Dedifferentiation involves NMDAR, mGluR2, DNA methylation and morphological changes. • Dedifferentiated cells express progenitor genes but also Müller identity genes. • Their early neuronal differentiati...

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Bibliographic Details
Published in:Neuroscience 2013-12, Vol.254, p.347-360
Main Authors: Reyes-Aguirre, L.I, Ferraro, S, Quintero, H, Sánchez-Serrano, S.L, Gómez-Montalvo, A, Lamas, M
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Dedifferentiation - drug effects
Cell Dedifferentiation - physiology
Cells, Cultured
dedifferentiation
DNA demethylation
Ependymoglial Cells - drug effects
Ependymoglial Cells - physiology
Epigenesis, Genetic - drug effects
Epigenesis, Genetic - physiology
epigenetic memory
Eye and associated structures. Visual pathways and centers. Vision
Fundamental and applied biological sciences. Psychology
Glutamic Acid - pharmacology
Müller glia
Neurology
neuronal differentiation
Phenotype
Photoreceptor Cells, Vertebrate - drug effects
Photoreceptor Cells, Vertebrate - physiology
Rats
Rats, Long-Evans
Retina - cytology
Retina - drug effects
Retina - physiology
retinal progenitors
Vertebrates: nervous system and sense organs
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Summary:Highlights • Glutamate triggers a rapid dedifferentiation response in rat Müller mature cells. • Dedifferentiation involves NMDAR, mGluR2, DNA methylation and morphological changes. • Dedifferentiated cells express progenitor genes but also Müller identity genes. • Their early neuronal differentiation potential is similar to retinal progenitors. • These cells fail to further differentiate to mature photoreceptor lineages.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.09.048