Advanced glycation of cellular proteins as a possible basic component of the “master biological clock”

During the last decade, evidence has been accumulating supporting the hypothesis that aging is genetically programmed and, therefore, precisely timed. This hypothesis poses a question: what is the mechanism of the biological clock that controls aging? Measuring the level of the advanced glycation en...

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Bibliographic Details
Published in:Biochemistry (Moscow) 2013-09, Vol.78 (9), p.1043-1047
Main Authors: Severin, F. F., Feniouk, B. A., Skulachev, V. P.
Format: Article
Language:English
Subjects:
Aging
Aging - genetics
Aging - metabolism
Aging - pathology
Animals
Apoptosis
Biochemistry
Biological clocks
Biological Clocks - physiology
Biological rhythms
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Glycation End Products, Advanced - metabolism
Glycoproteins
Hormones
Humans
Intracellular Signaling Peptides and Proteins - metabolism
Life Sciences
Melatonin
Mice
Microbiology
Phenoptosis
Physiological aspects
Proteins
Receptor for Advanced Glycation End Products
Receptors, Immunologic - metabolism
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Summary:During the last decade, evidence has been accumulating supporting the hypothesis that aging is genetically programmed and, therefore, precisely timed. This hypothesis poses a question: what is the mechanism of the biological clock that controls aging? Measuring the level of the advanced glycation end products (AGE) is one of the possible principles underlying the functioning of the biological clock. Protein glycation is an irreversible, non-enzymatic, and relatively slow process. Moreover, many types of cells have receptors that can measure AGE level. We propose the existence of a protein that has a lifespan comparable to that of the whole organism. Interaction of the advanced glycation end product generated from this protein with a specific AGE receptor might initiate apoptosis in a vitally important non-regenerating tissue that produces a primary juvenile hormone. This could result in the age-dependent decrease in the level of this hormone leading to aging of the organism.
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297913090101