Bladder Tumor Incidence Among Workers Exposed to Benzidine: A Thirty-Year Follow-up

Linkage with records of the Connecticut Tumor Registry was used to determine cancer incidence in a cohort of workers (n = 984) at a benzidine manufacturing facility. Compared to the findings for the Connecticut population, there was a statistically significant excess of bladder tumor among male coho...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1986-01, Vol.76 (1), p.1-8
Main Authors: Meigs, J. Wister, Marrett, Loraine D., Ulrich, Franziska U., Flannery, John T.
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Benzidines - toxicity
Biological and medical sciences
Connecticut
Female
Follow-Up Studies
Humans
Kidney Neoplasms - chemically induced
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Occupational Diseases - chemically induced
Occupational Diseases - epidemiology
Occupational Diseases - prevention & control
Registries
Time Factors
Tumors of the urinary system
Urinary Bladder Neoplasms - chemically induced
Urinary Bladder Neoplasms - epidemiology
Urinary Bladder Neoplasms - prevention & control
Urinary tract. Prostate gland
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Summary:Linkage with records of the Connecticut Tumor Registry was used to determine cancer incidence in a cohort of workers (n = 984) at a benzidine manufacturing facility. Compared to the findings for the Connecticut population, there was a statistically significant excess of bladder tumor among male cohort members [standardized incidence ratio (SIR)=343; 95% confidence limits (CL) = 148, 676; n = 830], which was confined to those with the highest estimated level of benzidine exposure (SIR = 1,303; CL=479, 2,839; n = 105). No significantly elevated risks were found for cancers at other anatomic sites in men or at any anatomic sites in women; nor was there any pattern of increasing risk with increasing benzidine exposure for sites other than bladder. In addition, the elevated bladder cancer risk was greater for men first employed during the earliest years of the plant, namely, 1945–49 (SIR = 976; CL=262, 2,498) as compared to those first employed in 1950–54 (SIR=213; CL=3, 1,184) after equalization of duration of follow-up. These results suggest that the major preventive measures instituted around 1950 may have reduced bladder cancer risk in this plant.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/76.1.1