TLR5 Stops Commensals in Their Tracks

IgA antibodies help maintain intestinal immune homeostasis with resident commensal species; however, the precise mechanisms regulating IgA induction and the epitopes recognized by these antibodies remain incompletely understood. In this issue of Cell Host & Microbe, Cullender et al. (2013) demon...

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Bibliographic Details
Published in:Cell host & microbe 2013-11, Vol.14 (5), p.488-490
Main Authors: Koch, Meghan A., Barton, Gregory M.
Format: Article
Language:English
Subjects:
Animals
Flagellin - immunology
Gastrointestinal Tract - immunology
Gastrointestinal Tract - microbiology
Immunity, Mucosal
Locomotion
Microbiota - immunology
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Summary:IgA antibodies help maintain intestinal immune homeostasis with resident commensal species; however, the precise mechanisms regulating IgA induction and the epitopes recognized by these antibodies remain incompletely understood. In this issue of Cell Host & Microbe, Cullender et al. (2013) demonstrate that TLR5-dependent induction of anti-flagellin antibodies prevents commensal association with the intestinal mucosa by limiting bacterial motility.
ISSN:1931-3128
1934-6069
DOI:10.1016/j.chom.2013.10.015