Effects of different growth factors and carriers on bone regeneration: a systematic review

Objective The application and subsequent investigations in the use of varied osteogenic growth factors in bone regeneration procedures have grown dramatically over the past several years. Owing to this rapid gain in popularity and documentation, a review was undertaken to evaluate the in vivo effect...

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Published in:Oral surgery, oral medicine, oral pathology and oral radiology oral medicine, oral pathology and oral radiology, 2013-12, Vol.116 (6), p.e405-e423
Main Authors: Khojasteh, Arash, DMD, MS, Behnia, Hossein, DMD, MS, Naghdi, Navid, Esmaeelinejad, Mohammad, Alikhassy, Zahra, Stevens, Mark, DMD, MS
Format: Article
Language:English
Subjects:
Animals
Bone Morphogenetic Protein 2 - pharmacology
Bone Regeneration - drug effects
Dentistry
Drug Carriers - pharmacology
Humans
Intercellular Signaling Peptides and Proteins - pharmacology
Models, Animal
Osteogenesis - drug effects
Surgery
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Summary:Objective The application and subsequent investigations in the use of varied osteogenic growth factors in bone regeneration procedures have grown dramatically over the past several years. Owing to this rapid gain in popularity and documentation, a review was undertaken to evaluate the in vivo effects of growth factors on bone regeneration. Study Design Using related key words, electronic databases (Medline, Embase, and Cochrane) were searched for articles published from 1999 to April 2010 to find growth factor application in bone regeneration in human or animal models. Results A total of 63 articles were matched with the inclusion criteria of this study. Bone morphogenetic protein 2 (BMP-2) was the most studied growth factor. Carriers for the delivery, experimental sites, and methods of evaluation were different, and therefore articles did not come to a general agreement. Conclusions Within the limitations of this review, BMP-2 may be an appropriate growth factor for osteogenesis.
ISSN:2212-4403
2212-4411
DOI:10.1016/j.oooo.2012.01.044