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A new rapid test for fecal calprotectin predicts endoscopic remission and postoperative recurrence in Crohn's disease
Fecal calprotectin (FC), as determined by the enzyme-linked immunoassay (ELISA) test, has been proposed as a promising biomarker of endoscopic activity in Crohn's disease (CD). However data on its accuracy in predicting endoscopic remission according to location and postoperative recurrence (PO...
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| Published in: | Journal of Crohn's and colitis 2013-12, Vol.7 (12), p.e641-e651 |
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| container_end_page | e651 |
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| container_start_page | e641 |
| container_title | Journal of Crohn's and colitis |
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| creator | Lobatón, Triana López-García, Alicia Rodríguez-Moranta, Francisco Ruiz, Alexandra Rodríguez, Lorena Guardiola, Jordi |
| description | Fecal calprotectin (FC), as determined by the enzyme-linked immunoassay (ELISA) test, has been proposed as a promising biomarker of endoscopic activity in Crohn's disease (CD). However data on its accuracy in predicting endoscopic remission according to location and postoperative recurrence (POR) is scarce.
Our objective was to evaluate the ability of FC determined by a new quantitative point-of-care test (FC-QPOCT) to predict endoscopic remission and POR in CD patients.
FC was determined simultaneously by an enzyme-linked immunoassay test (FC-ELISA) and a FC-QPOCT in CD patients undergoing colonoscopy. Clinical disease activity was assessed according to the Crohn's Disease Activity Index (CDAI). Endoscopic results were assessed according to the Crohn's Disease Endoscopic Activity Index of Severity (CDEIS) and postoperative recurrence according to the Rutgeerts' score.
A total of 115 ileocolonoscopies were performed (29 on patients with ileocolonic resection). FC levels correlated more closely with the CDEIS than leucocytes, platelets or CRP. The prediction of “endoscopic remission” (CDEIS |
| doi_str_mv | 10.1016/j.crohns.2013.05.005 |
| format | article |
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Our objective was to evaluate the ability of FC determined by a new quantitative point-of-care test (FC-QPOCT) to predict endoscopic remission and POR in CD patients.
FC was determined simultaneously by an enzyme-linked immunoassay test (FC-ELISA) and a FC-QPOCT in CD patients undergoing colonoscopy. Clinical disease activity was assessed according to the Crohn's Disease Activity Index (CDAI). Endoscopic results were assessed according to the Crohn's Disease Endoscopic Activity Index of Severity (CDEIS) and postoperative recurrence according to the Rutgeerts' score.
A total of 115 ileocolonoscopies were performed (29 on patients with ileocolonic resection). FC levels correlated more closely with the CDEIS than leucocytes, platelets or CRP. The prediction of “endoscopic remission” (CDEIS<3), using FC-QPOCT (cut-off 272μg/g) and FC-ELISA (cut-off 274μg/g) presented an AUC of 0.933 and 0.935 respectively. FC-QPOCT results correlated better with endoscopic activity in the ileocolonic location (Pearson's correlation, r=0.879; P<0.001), than the colonic (r=0.725; P<0.001) or the ileal location (r=0.437; P=0.016). Median FC-QPOCT levels discriminated Rutgeerts' score i0–i1 from i2–i4 (98 (range 30–306)μg/g vs. 234.5 (range 100–612)μg/g respectively, P=0.012).
FC determined by rapid quantitative test predicts “endoscopic remission” and endoscopic postoperative recurrence in CD patients.</description><identifier>ISSN: 1873-9946</identifier><identifier>EISSN: 1876-4479</identifier><identifier>DOI: 10.1016/j.crohns.2013.05.005</identifier><identifier>PMID: 23810085</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Adult ; Biomarkers - analysis ; C-Reactive Protein - metabolism ; Colon - pathology ; Colon - surgery ; Colonoscopy - utilization ; Crohn Disease - metabolism ; Crohn Disease - pathology ; Crohn Disease - surgery ; Crohn's disease ; Endoscopic activity ; Enzyme-Linked Immunosorbent Assay ; Fecal calprotectin ; Feces - chemistry ; Female ; Humans ; Ileum - pathology ; Ileum - surgery ; Leukocyte L1 Antigen Complex - analysis ; Male ; Middle Aged ; Point-of-Care Systems ; Postoperative Period ; Predictive Value of Tests ; Recurrence ; Severity of Illness Index</subject><ispartof>Journal of Crohn's and colitis, 2013-12, Vol.7 (12), p.e641-e651</ispartof><rights>2013 European Crohn's and Colitis Organisation</rights><rights>Copyright © 2013 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3895-54ee3c16b4ecb96a3d63b31692bedeb982b1266fb5473d75f79b7ff95413df5a3</citedby><cites>FETCH-LOGICAL-c3895-54ee3c16b4ecb96a3d63b31692bedeb982b1266fb5473d75f79b7ff95413df5a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23810085$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lobatón, Triana</creatorcontrib><creatorcontrib>López-García, Alicia</creatorcontrib><creatorcontrib>Rodríguez-Moranta, Francisco</creatorcontrib><creatorcontrib>Ruiz, Alexandra</creatorcontrib><creatorcontrib>Rodríguez, Lorena</creatorcontrib><creatorcontrib>Guardiola, Jordi</creatorcontrib><title>A new rapid test for fecal calprotectin predicts endoscopic remission and postoperative recurrence in Crohn's disease</title><title>Journal of Crohn's and colitis</title><addtitle>J Crohns Colitis</addtitle><description>Fecal calprotectin (FC), as determined by the enzyme-linked immunoassay (ELISA) test, has been proposed as a promising biomarker of endoscopic activity in Crohn's disease (CD). However data on its accuracy in predicting endoscopic remission according to location and postoperative recurrence (POR) is scarce.
Our objective was to evaluate the ability of FC determined by a new quantitative point-of-care test (FC-QPOCT) to predict endoscopic remission and POR in CD patients.
FC was determined simultaneously by an enzyme-linked immunoassay test (FC-ELISA) and a FC-QPOCT in CD patients undergoing colonoscopy. Clinical disease activity was assessed according to the Crohn's Disease Activity Index (CDAI). Endoscopic results were assessed according to the Crohn's Disease Endoscopic Activity Index of Severity (CDEIS) and postoperative recurrence according to the Rutgeerts' score.
A total of 115 ileocolonoscopies were performed (29 on patients with ileocolonic resection). FC levels correlated more closely with the CDEIS than leucocytes, platelets or CRP. The prediction of “endoscopic remission” (CDEIS<3), using FC-QPOCT (cut-off 272μg/g) and FC-ELISA (cut-off 274μg/g) presented an AUC of 0.933 and 0.935 respectively. FC-QPOCT results correlated better with endoscopic activity in the ileocolonic location (Pearson's correlation, r=0.879; P<0.001), than the colonic (r=0.725; P<0.001) or the ileal location (r=0.437; P=0.016). Median FC-QPOCT levels discriminated Rutgeerts' score i0–i1 from i2–i4 (98 (range 30–306)μg/g vs. 234.5 (range 100–612)μg/g respectively, P=0.012).
FC determined by rapid quantitative test predicts “endoscopic remission” and endoscopic postoperative recurrence in CD patients.</description><subject>Adult</subject><subject>Biomarkers - analysis</subject><subject>C-Reactive Protein - metabolism</subject><subject>Colon - pathology</subject><subject>Colon - surgery</subject><subject>Colonoscopy - utilization</subject><subject>Crohn Disease - metabolism</subject><subject>Crohn Disease - pathology</subject><subject>Crohn Disease - surgery</subject><subject>Crohn's disease</subject><subject>Endoscopic activity</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Fecal calprotectin</subject><subject>Feces - chemistry</subject><subject>Female</subject><subject>Humans</subject><subject>Ileum - pathology</subject><subject>Ileum - surgery</subject><subject>Leukocyte L1 Antigen Complex - analysis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Point-of-Care Systems</subject><subject>Postoperative Period</subject><subject>Predictive Value of Tests</subject><subject>Recurrence</subject><subject>Severity of Illness Index</subject><issn>1873-9946</issn><issn>1876-4479</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9kE2LFDEQhoMo7jr6D0Ry00u3SeejOxdhGfyCBS96DvmoYIaZTpvqXvHfb2Zn9eghVKDet6reh5DXnPWccf3-0Idafs7YD4yLnqmeMfWEXPNp1J2Uo3n68BedMVJfkReIhyYwapyek6tBTJyxSV2T7YbO8JtWt-RIV8CVplJpguCOtL2llhXCmme6VIg5rEhhjgVDWXKgFU4ZMZeZujnSpeBaFqhuzXfQemGrFeYAtLn351PfIo0ZwSG8JM-SOyK8eqw78uPTx-_7L93tt89f9ze3XRCTUZ2SACJw7SUEb7QTUQsvuDaDhwjeTIPng9bJKzmKOKo0Gj-mZJTkIiblxI68u8xtOX5tLZ1tBwc4Ht0MZUPLZSOiHvQ7Ii_SRhWxQrJLzSdX_1jO7Bm4PdgLcHsGbpmyjWezvXncsPkTxH-mv4Sb4MNFAC3nXYZqMeQzlpgbotXGkv-_4R42lpYB</recordid><startdate>201312</startdate><enddate>201312</enddate><creator>Lobatón, Triana</creator><creator>López-García, Alicia</creator><creator>Rodríguez-Moranta, Francisco</creator><creator>Ruiz, Alexandra</creator><creator>Rodríguez, Lorena</creator><creator>Guardiola, Jordi</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201312</creationdate><title>A new rapid test for fecal calprotectin predicts endoscopic remission and postoperative recurrence in Crohn's disease</title><author>Lobatón, Triana ; López-García, Alicia ; Rodríguez-Moranta, Francisco ; Ruiz, Alexandra ; Rodríguez, Lorena ; Guardiola, Jordi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3895-54ee3c16b4ecb96a3d63b31692bedeb982b1266fb5473d75f79b7ff95413df5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Biomarkers - analysis</topic><topic>C-Reactive Protein - metabolism</topic><topic>Colon - pathology</topic><topic>Colon - surgery</topic><topic>Colonoscopy - utilization</topic><topic>Crohn Disease - metabolism</topic><topic>Crohn Disease - pathology</topic><topic>Crohn Disease - surgery</topic><topic>Crohn's disease</topic><topic>Endoscopic activity</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Fecal calprotectin</topic><topic>Feces - chemistry</topic><topic>Female</topic><topic>Humans</topic><topic>Ileum - pathology</topic><topic>Ileum - surgery</topic><topic>Leukocyte L1 Antigen Complex - analysis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Point-of-Care Systems</topic><topic>Postoperative Period</topic><topic>Predictive Value of Tests</topic><topic>Recurrence</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lobatón, Triana</creatorcontrib><creatorcontrib>López-García, Alicia</creatorcontrib><creatorcontrib>Rodríguez-Moranta, Francisco</creatorcontrib><creatorcontrib>Ruiz, Alexandra</creatorcontrib><creatorcontrib>Rodríguez, Lorena</creatorcontrib><creatorcontrib>Guardiola, Jordi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Crohn's and colitis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lobatón, Triana</au><au>López-García, Alicia</au><au>Rodríguez-Moranta, Francisco</au><au>Ruiz, Alexandra</au><au>Rodríguez, Lorena</au><au>Guardiola, Jordi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new rapid test for fecal calprotectin predicts endoscopic remission and postoperative recurrence in Crohn's disease</atitle><jtitle>Journal of Crohn's and colitis</jtitle><addtitle>J Crohns Colitis</addtitle><date>2013-12</date><risdate>2013</risdate><volume>7</volume><issue>12</issue><spage>e641</spage><epage>e651</epage><pages>e641-e651</pages><issn>1873-9946</issn><eissn>1876-4479</eissn><abstract>Fecal calprotectin (FC), as determined by the enzyme-linked immunoassay (ELISA) test, has been proposed as a promising biomarker of endoscopic activity in Crohn's disease (CD). However data on its accuracy in predicting endoscopic remission according to location and postoperative recurrence (POR) is scarce.
Our objective was to evaluate the ability of FC determined by a new quantitative point-of-care test (FC-QPOCT) to predict endoscopic remission and POR in CD patients.
FC was determined simultaneously by an enzyme-linked immunoassay test (FC-ELISA) and a FC-QPOCT in CD patients undergoing colonoscopy. Clinical disease activity was assessed according to the Crohn's Disease Activity Index (CDAI). Endoscopic results were assessed according to the Crohn's Disease Endoscopic Activity Index of Severity (CDEIS) and postoperative recurrence according to the Rutgeerts' score.
A total of 115 ileocolonoscopies were performed (29 on patients with ileocolonic resection). FC levels correlated more closely with the CDEIS than leucocytes, platelets or CRP. The prediction of “endoscopic remission” (CDEIS<3), using FC-QPOCT (cut-off 272μg/g) and FC-ELISA (cut-off 274μg/g) presented an AUC of 0.933 and 0.935 respectively. FC-QPOCT results correlated better with endoscopic activity in the ileocolonic location (Pearson's correlation, r=0.879; P<0.001), than the colonic (r=0.725; P<0.001) or the ileal location (r=0.437; P=0.016). Median FC-QPOCT levels discriminated Rutgeerts' score i0–i1 from i2–i4 (98 (range 30–306)μg/g vs. 234.5 (range 100–612)μg/g respectively, P=0.012).
FC determined by rapid quantitative test predicts “endoscopic remission” and endoscopic postoperative recurrence in CD patients.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>23810085</pmid><doi>10.1016/j.crohns.2013.05.005</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1873-9946 |
| ispartof | Journal of Crohn's and colitis, 2013-12, Vol.7 (12), p.e641-e651 |
| issn | 1873-9946 1876-4479 |
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| source | Oxford Journals Online |
| subjects | Adult Biomarkers - analysis C-Reactive Protein - metabolism Colon - pathology Colon - surgery Colonoscopy - utilization Crohn Disease - metabolism Crohn Disease - pathology Crohn Disease - surgery Crohn's disease Endoscopic activity Enzyme-Linked Immunosorbent Assay Fecal calprotectin Feces - chemistry Female Humans Ileum - pathology Ileum - surgery Leukocyte L1 Antigen Complex - analysis Male Middle Aged Point-of-Care Systems Postoperative Period Predictive Value of Tests Recurrence Severity of Illness Index |
| title | A new rapid test for fecal calprotectin predicts endoscopic remission and postoperative recurrence in Crohn's disease |
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