Increased Risk of Pneumonia and Bronchiolitis after Bacterial Colonization of the Airways as Neonates

• Published in: American journal of respiratory and critical care medicine 2013-11, Vol.188 (10), p.1246-1252
• Main Authors: VISSING, Nadja H, CHAWES, Bo L. K, BISGAARD, Hans
• Format: Article
• Language: English
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Asthma; Asthma - diagnosis; Asthma - epidemiology; Asthma - microbiology; Biological and medical sciences; Breastfeeding & lactation; Bronchiolitis - diagnosis; Bronchiolitis - epidemiology; Bronchiolitis - microbiology; Child, Preschool; Children & youth; Chronic obstructive pulmonary disease, asthma; Cohort analysis; Denmark - epidemiology; Family physicians; Female; Follow-Up Studies; Haemophilus influenzae - isolation & purification; Humans; Hypopharynx - microbiology; Incidence; Infant; Infant, Newborn; Intensive care medicine; Kaplan-Meier Estimate; Male; Medical sciences; Microbiota; Moraxella (Branhamella) catarrhalis - isolation & purification; Parents & parenting; Pneumology; Pneumonia; Pneumonia - diagnosis; Pneumonia - epidemiology; Pneumonia - microbiology; Proportional Hazards Models; Prospective Studies; Risk Factors; Staphylococcus aureus - isolation & purification; Streptococcus infections; Streptococcus pneumoniae - isolation & purification
• ISSN: 1073-449X; 1535-4970
• DOI: 10.1164/rccm.201302-0215OC

The frequency of pneumonia and bronchiolitis exhibits considerable variation in otherwise healthy children, and suspected risk factors explain only a minor proportion of the variation. We hypothesized that alterations in the airway microbiome in early life may be associated with susceptibility to pneumonia and bronchiolitis in young children. To investigate the relation between neonatal airway colonization and pneumonia and bronchiolitis during the first 3 years of life. Participants comprised children of the Copenhagen Prospective Studies on Asthma in Childhood2000 (COPSAC2000) cohort, a prospective birth cohort study of 411 children born to mothers with asthma. Aspirates from the hypopharynx at age 4 weeks were cultured for Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Staphylococcus aureus. Clinical information on pneumonia and bronchiolitis within the first 3 years of life was prospectively collected by the research physicians at the center. Analyses were adjusted for covariates associated with pneumonia and bronchiolitis and bacterial airway colonization. Hypopharyngeal aspirates and full clinical follow-up until 3 years of age were available for 265 children. Of these, 56 (21%) neonates were colonized with S. pneumoniae, H. influenzae, and/or M. catarrhalis at 4 weeks of age. Colonization with at least one of these microorganisms (but not S. aureus) was significantly associated with increased incidence of pneumonia and bronchiolitis (adjusted incidence rate ratio, 1.79 [1.29-2.48]; P < 0.005) independently of concurrent or later asthma. Neonatal airway colonization with S. pneumoniae, H. influenzae, or M. catarrhalis is associated with increased risk of pneumonia and bronchiolitis in early life independently of asthma. This suggests a role of pathogenic bacterial colonization of the airways in neonates for subsequent susceptibly to pneumonia and bronchiolitis.