A Predictive-Adaptive, Multipoint Feedback Controller for Local Heat Therapy of Solid Tumors

Uniform heating of tumor tissue to therapeutic temperatures without damaging surrounding normal tissue is required for optimal local heat therapy of cancer. This paper describes an algorithm for on-line computer control that will allow the therapist to minimize the standard deviation of measured int...

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Bibliographic Details
Published in:IEEE transactions on microwave theory and techniques 1986-05, Vol.34 (5), p.604-611
Main Authors: Babbs, C.F., Vaguine, V.A., Jones, J.T.
Format: Article
Language:English
Subjects:
Adaptive control
Applicators
Biological and medical sciences
computer applications
control systems
Equations
hyperthermia
Induced hyperthermia. Cryotherapy
Medical sciences
Medical treatment
microwaves
Neoplasms
Solids
Temperature control
Temperature distribution
Temperature measurement
Temperature sensors
tissues
Treatment with physical agents
Treatment. General aspects
Tumors
ultrasonics
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Summary:Uniform heating of tumor tissue to therapeutic temperatures without damaging surrounding normal tissue is required for optimal local heat therapy of cancer. This paper describes an algorithm for on-line computer control that will allow the therapist to minimize the standard deviation of measured intratumoral temperatures. The method is applicable to systems incorporating multiple surface and/or interstitial applicators delivering microwave, radiofrequency, or ultrasonic power and operating under control of a small computer. The essential element is a novel predictive-adaptive control algorithm that infers relevant thermal parameters from the responses of multiple temperature sensors as each of the power applicators is briefly turned off. Applied power and effective perfusion are estimated from transient slope changes of the temperature-time curves for each sensor. By substituting these values into a system of linear equations derived from the bio-heat transfer equation, the small computer can calculate the optimal allocation of power among the various applicators ("knob settings") to generate most uniform intratumoral temperature distribution with the desired mean, or minimum, tumor temperature.
ISSN:0018-9480
1557-9670
DOI:10.1109/TMTT.1986.1133399