Physiological constraints in increasing biomass concentration of Escherichia coli B in fed-batch culture

Fed-batch culture of E. coli B was carried out to obtain high concentration of biomass. After requirement of oxygen was met by sparging the pure oxygen, physiological constraints were delineated. High partial pressure of CO sub(2) caused the decrease of the maximum specific growth rate, whereas ferm...

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Bibliographic Details
Published in:Biotechnology letters 1987-01, Vol.9 (2), p.89-94
Main Authors: JAE GU PAN, JOON SHICK RHEE, LEBEAULT, J. M
Format: Article
Language:English
Subjects:
batch culture
Biological and medical sciences
biomass
Biotechnology
Escherichia coli
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
Microbial engineering. Fermentation and microbial culture technology
Online Access:Get full text
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Summary:Fed-batch culture of E. coli B was carried out to obtain high concentration of biomass. After requirement of oxygen was met by sparging the pure oxygen, physiological constraints were delineated. High partial pressure of CO sub(2) caused the decrease of the maximum specific growth rate, whereas fermentative byproducts caused the decrease of biomass yield as well as the maximum specific growth rate.
ISSN:0141-5492
1573-6776
DOI:10.1007/BF01032744