Cytokine and Chemokine Levels in Patients Infected With the Novel Avian Influenza A (H7N9) Virus in China

H7N9 avian influenza is an emerging viral disease in China caused by avian influenza A (H7N9) virus. We investigated host cytokine and chemokine profiles in serum samples of H7N9 patients by multiplex-microbead immunoassays. Statistical analysis showed that IP-10, IL-6, IL-17, and IL-2 were increase...

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Bibliographic Details
Published in:The Journal of infectious diseases 2013-12, Vol.208 (12), p.1962-1967
Main Authors: Chi, Ying, Zhu, Yefei, Wen, Tian, Cui, Lunbiao, Ge, Yiyue, Jiao, Yongjun, Wu, Tao, Ge, Aihua, Ji, Hong, Xu, Ke, Bao, Changjun, Zhu, Zheng, Qi, Xian, Wu, Bin, Shi, Zhiyang, Tang, Fenyang, Xing, Zheng, Zhou, Minghao
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
China - epidemiology
Cytokines - blood
Cytokines - immunology
Female
Fundamental and applied biological sciences. Psychology
Humans
Infectious diseases
Influenza A Virus, H7N9 Subtype - immunology
Influenza, Human - blood
Influenza, Human - epidemiology
Influenza, Human - immunology
Influenza, Human - virology
Male
Medical sciences
Microbiology
Middle Aged
Miscellaneous
Virology
VIRUSES
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Summary:H7N9 avian influenza is an emerging viral disease in China caused by avian influenza A (H7N9) virus. We investigated host cytokine and chemokine profiles in serum samples of H7N9 patients by multiplex-microbead immunoassays. Statistical analysis showed that IP-10, IL-6, IL-17, and IL-2 were increased in H7N9 infected patients. Furthermore, IL-6 and the chemokine IP-10 were significantly higher in severe H7N9 patients compared to nonsevere H7N9 cases. We suggest that proinflammatory cytokine responses, characterized by a combined Th1/Th17 cytokine induction, are partially responsible for the disease progression of patients with H7N9 infection.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jit440