Clinical features of recurrent Kawasaki disease and its risk factors

• Published in: European journal of pediatrics 2013-12, Vol.172 (12), p.1641-1647
• Main Authors: Yang, Hai-ming, Du, Zhong-Dong, Fu, Pei-pei
• Format: Article
• Language: English
• Subjects: Alanine Transaminase - analysis; Aspartate Aminotransferases - analysis; Blood Sedimentation; C-Reactive Protein - analysis; Child; Child, Preschool; Coronary vessels; Coronary Vessels - diagnostic imaging; Coronary Vessels - physiopathology; Echocardiography; Female; Fever; Hemoglobin; Hemoglobins - analysis; Hospitals; Humans; Immunoglobulins, Intravenous - administration & dosage; Infant; Kawasaki disease; Laboratories; Leukocytes; Logistic Models; Medical records; Medicine; Medicine & Public Health; Mucocutaneous Lymph Node Syndrome - metabolism; Mucocutaneous Lymph Node Syndrome - physiopathology; Mucocutaneous Lymph Node Syndrome - therapy; Original Article; Pediatrics; Recurrence; Retrospective Studies; Risk Factors; ROC Curve; Veins & arteries
• ISSN: 0340-6199; 1432-1076
• DOI: 10.1007/s00431-013-2101-9

The clinical features and risk factors for recurrence of Kawasaki disease (KD) remain unclear. In order to summarize clinical features of recurrent KD and identify risk factors associated with recurrence, we conducted a retrospective review of the medical records of consecutive cases of KD from January 2002 to December 2010. Demographic, clinical, laboratory, and echocardiographic data were analyzed. The maximum coronary artery Z score normalized against body surface area was assessed using coronary artery diameters. At the first onset of recurrent KD, children had longer durations of fever before intravenous immunoglobulin (IVIG) treatment and higher levels of alanine aminotransferase, serum aspartate aminotransferase (AST), and lower hemoglobin levels than those with a single episode of KD. Multivariate logistic regression analysis showed that long durations of fever before IVIG treatment, high AST levels, and reduced hemoglobin levels were significantly associated with recurrent KD. Ten of the 22 recurrent KD children had coronary artery complications during the first onset episode, and six (60 %) of these also had coronary artery complications during the recurrence. Children with longer durations of fever, lower hemoglobin levels, and higher AST levels may be at increased risk for KD and coronary artery complications are more likely to occur in children with recurrent KD if they were present during the first episode.