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Adipocytokine levels in women with anorexia nervosa. Relationship with weight restoration and disease duration

ABSTRACT Objective Starvation‐induced depletion of fat stores in anorexia nervosa (AN) is known to be accompanied by alterations in some circulating adipocytokines. We analyzed a panel of circulating adipocytokines in women with AN compared with normal‐weight controls and their relation with the dis...

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Published in:The International journal of eating disorders 2013-12, Vol.46 (8), p.855-861
Main Authors: Terra, Ximena, Auguet, Teresa, Agüera, Zaida, Quesada, Isabel Maria, Orellana-Gavaldà, Josep Maria, Aguilar, Carmen, Jiménez-Murcia, Susana, Berlanga, Alba, Guiu-Jurado, Esther, Menchón, José Manuel, Fernández-Aranda, Fernando, Richart, Cristóbal
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creator Terra, Ximena
Auguet, Teresa
Agüera, Zaida
Quesada, Isabel Maria
Orellana-Gavaldà, Josep Maria
Aguilar, Carmen
Jiménez-Murcia, Susana
Berlanga, Alba
Guiu-Jurado, Esther
Menchón, José Manuel
Fernández-Aranda, Fernando
Richart, Cristóbal
description ABSTRACT Objective Starvation‐induced depletion of fat stores in anorexia nervosa (AN) is known to be accompanied by alterations in some circulating adipocytokines. We analyzed a panel of circulating adipocytokines in women with AN compared with normal‐weight controls and their relation with the disease duration and weight restoration. Method We analyzed circulating adipocytokine levels in 28 patients with AN and in 33 normal‐weight controls who were eating healthily. We determined by enzyme‐linked immunosorbent assay the circulating levels of total and high molecular weight (HMW) adiponectin, lipocalin‐2 (LCN2), leptin, tumor necrosis factor receptor‐II (TNFRII), interleukin‐6 (IL6), adipocyte fatty acid binding protein‐4 (FABP4), ghrelin, and resistin. Results The two circulating forms of adiponectin are higher in AN women compared with controls. Both total and HMW adiponectin related negatively to the duration of the disease (r = −0.372, p = 0.033; r = −0.450, p = 0.038, respectively). Furthermore, the lipid binding‐proteins LCN2 and FABP4 are lower in AN compared to the control group. Finally, leptin levels are lower in AN against controls and correlated positively with disease duration (r = 0.537, p = 0.007). Resistin, ghrelin, TNFRII, and IL6 have similar values in both groups, although TNFRII and ghrelin related negatively to body mass index variation at the end of treatment (r = −0.456, p = 0.039; r = −0.536, p = 0.015, respectively). Discussion These results suggest there is a need to investigate if changes in adipocytokine levels could serve as weight restoration biomarkers. Further studies are warranted to elucidate the specific role of these molecules in the timing of weight restoration. © 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2013; 46:855–861)
doi_str_mv 10.1002/eat.22166
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Relationship with weight restoration and disease duration</title><source>Wiley</source><creator>Terra, Ximena ; Auguet, Teresa ; Agüera, Zaida ; Quesada, Isabel Maria ; Orellana-Gavaldà, Josep Maria ; Aguilar, Carmen ; Jiménez-Murcia, Susana ; Berlanga, Alba ; Guiu-Jurado, Esther ; Menchón, José Manuel ; Fernández-Aranda, Fernando ; Richart, Cristóbal</creator><creatorcontrib>Terra, Ximena ; Auguet, Teresa ; Agüera, Zaida ; Quesada, Isabel Maria ; Orellana-Gavaldà, Josep Maria ; Aguilar, Carmen ; Jiménez-Murcia, Susana ; Berlanga, Alba ; Guiu-Jurado, Esther ; Menchón, José Manuel ; Fernández-Aranda, Fernando ; Richart, Cristóbal</creatorcontrib><description>ABSTRACT Objective Starvation‐induced depletion of fat stores in anorexia nervosa (AN) is known to be accompanied by alterations in some circulating adipocytokines. We analyzed a panel of circulating adipocytokines in women with AN compared with normal‐weight controls and their relation with the disease duration and weight restoration. Method We analyzed circulating adipocytokine levels in 28 patients with AN and in 33 normal‐weight controls who were eating healthily. We determined by enzyme‐linked immunosorbent assay the circulating levels of total and high molecular weight (HMW) adiponectin, lipocalin‐2 (LCN2), leptin, tumor necrosis factor receptor‐II (TNFRII), interleukin‐6 (IL6), adipocyte fatty acid binding protein‐4 (FABP4), ghrelin, and resistin. Results The two circulating forms of adiponectin are higher in AN women compared with controls. Both total and HMW adiponectin related negatively to the duration of the disease (r = −0.372, p = 0.033; r = −0.450, p = 0.038, respectively). Furthermore, the lipid binding‐proteins LCN2 and FABP4 are lower in AN compared to the control group. Finally, leptin levels are lower in AN against controls and correlated positively with disease duration (r = 0.537, p = 0.007). Resistin, ghrelin, TNFRII, and IL6 have similar values in both groups, although TNFRII and ghrelin related negatively to body mass index variation at the end of treatment (r = −0.456, p = 0.039; r = −0.536, p = 0.015, respectively). Discussion These results suggest there is a need to investigate if changes in adipocytokine levels could serve as weight restoration biomarkers. Further studies are warranted to elucidate the specific role of these molecules in the timing of weight restoration. © 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2013; 46:855–861)</description><identifier>ISSN: 0276-3478</identifier><identifier>EISSN: 1098-108X</identifier><identifier>DOI: 10.1002/eat.22166</identifier><identifier>PMID: 23881663</identifier><identifier>CODEN: INDIDJ</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>adipocytokines ; Adipokines - blood ; Adiponectin - blood ; Adult ; Anorexia ; anorexia nervosa ; Anorexia Nervosa - blood ; Anorexia Nervosa - diagnosis ; Anorexia Nervosa - metabolism ; Biomarkers ; Biomarkers - blood ; Body Mass Index ; Body Weight - physiology ; Case-Control Studies ; Eating disorders ; Fatty Acid-Binding Proteins - blood ; Female ; Ghrelin - blood ; Humans ; Interview, Psychological ; Leptin - metabolism ; Molecular weight ; Resistin - blood ; Risk Assessment ; Spain ; Weight control ; weight restoration ; Womens health</subject><ispartof>The International journal of eating disorders, 2013-12, Vol.46 (8), p.855-861</ispartof><rights>Copyright © 2013 Wiley Periodicals, Inc.</rights><rights>Copyright Wiley Subscription Services, Inc. Dec 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3916-2fe96547e225b2b94071842e44586a553649f1dc8b15d8227fcffdaf85ac32a33</citedby><cites>FETCH-LOGICAL-c3916-2fe96547e225b2b94071842e44586a553649f1dc8b15d8227fcffdaf85ac32a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23881663$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Terra, Ximena</creatorcontrib><creatorcontrib>Auguet, Teresa</creatorcontrib><creatorcontrib>Agüera, Zaida</creatorcontrib><creatorcontrib>Quesada, Isabel Maria</creatorcontrib><creatorcontrib>Orellana-Gavaldà, Josep Maria</creatorcontrib><creatorcontrib>Aguilar, Carmen</creatorcontrib><creatorcontrib>Jiménez-Murcia, Susana</creatorcontrib><creatorcontrib>Berlanga, Alba</creatorcontrib><creatorcontrib>Guiu-Jurado, Esther</creatorcontrib><creatorcontrib>Menchón, José Manuel</creatorcontrib><creatorcontrib>Fernández-Aranda, Fernando</creatorcontrib><creatorcontrib>Richart, Cristóbal</creatorcontrib><title>Adipocytokine levels in women with anorexia nervosa. Relationship with weight restoration and disease duration</title><title>The International journal of eating disorders</title><addtitle>Int. J. Eat. Disord</addtitle><description>ABSTRACT Objective Starvation‐induced depletion of fat stores in anorexia nervosa (AN) is known to be accompanied by alterations in some circulating adipocytokines. We analyzed a panel of circulating adipocytokines in women with AN compared with normal‐weight controls and their relation with the disease duration and weight restoration. Method We analyzed circulating adipocytokine levels in 28 patients with AN and in 33 normal‐weight controls who were eating healthily. We determined by enzyme‐linked immunosorbent assay the circulating levels of total and high molecular weight (HMW) adiponectin, lipocalin‐2 (LCN2), leptin, tumor necrosis factor receptor‐II (TNFRII), interleukin‐6 (IL6), adipocyte fatty acid binding protein‐4 (FABP4), ghrelin, and resistin. Results The two circulating forms of adiponectin are higher in AN women compared with controls. Both total and HMW adiponectin related negatively to the duration of the disease (r = −0.372, p = 0.033; r = −0.450, p = 0.038, respectively). Furthermore, the lipid binding‐proteins LCN2 and FABP4 are lower in AN compared to the control group. Finally, leptin levels are lower in AN against controls and correlated positively with disease duration (r = 0.537, p = 0.007). Resistin, ghrelin, TNFRII, and IL6 have similar values in both groups, although TNFRII and ghrelin related negatively to body mass index variation at the end of treatment (r = −0.456, p = 0.039; r = −0.536, p = 0.015, respectively). Discussion These results suggest there is a need to investigate if changes in adipocytokine levels could serve as weight restoration biomarkers. Further studies are warranted to elucidate the specific role of these molecules in the timing of weight restoration. © 2013 Wiley Periodicals, Inc. 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We determined by enzyme‐linked immunosorbent assay the circulating levels of total and high molecular weight (HMW) adiponectin, lipocalin‐2 (LCN2), leptin, tumor necrosis factor receptor‐II (TNFRII), interleukin‐6 (IL6), adipocyte fatty acid binding protein‐4 (FABP4), ghrelin, and resistin. Results The two circulating forms of adiponectin are higher in AN women compared with controls. Both total and HMW adiponectin related negatively to the duration of the disease (r = −0.372, p = 0.033; r = −0.450, p = 0.038, respectively). Furthermore, the lipid binding‐proteins LCN2 and FABP4 are lower in AN compared to the control group. Finally, leptin levels are lower in AN against controls and correlated positively with disease duration (r = 0.537, p = 0.007). Resistin, ghrelin, TNFRII, and IL6 have similar values in both groups, although TNFRII and ghrelin related negatively to body mass index variation at the end of treatment (r = −0.456, p = 0.039; r = −0.536, p = 0.015, respectively). Discussion These results suggest there is a need to investigate if changes in adipocytokine levels could serve as weight restoration biomarkers. Further studies are warranted to elucidate the specific role of these molecules in the timing of weight restoration. © 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2013; 46:855–861)</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>23881663</pmid><doi>10.1002/eat.22166</doi><tpages>7</tpages></addata></record>
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identifier ISSN: 0276-3478
ispartof The International journal of eating disorders, 2013-12, Vol.46 (8), p.855-861
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subjects adipocytokines
Adipokines - blood
Adiponectin - blood
Adult
Anorexia
anorexia nervosa
Anorexia Nervosa - blood
Anorexia Nervosa - diagnosis
Anorexia Nervosa - metabolism
Biomarkers
Biomarkers - blood
Body Mass Index
Body Weight - physiology
Case-Control Studies
Eating disorders
Fatty Acid-Binding Proteins - blood
Female
Ghrelin - blood
Humans
Interview, Psychological
Leptin - metabolism
Molecular weight
Resistin - blood
Risk Assessment
Spain
Weight control
weight restoration
Womens health
title Adipocytokine levels in women with anorexia nervosa. Relationship with weight restoration and disease duration
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