Effect of Levosimendan on Survival and Adverse Events After Cardiac Surgery: A Meta-Analysis

Objective Left ventricular systolic dysfunction is associated with increased morbidity and mortality in patients undergoing cardiac surgery. The authors performed a meta-analysis investigating the effects of levosimendan in cardiac surgery patients with and without preoperative systolic dysfunction....

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Bibliographic Details
Published in:Journal of cardiothoracic and vascular anesthesia 2013-12, Vol.27 (6), p.1224-1232
Main Authors: Harrison, Robert W., MD, Hasselblad, Vic, PhD, Mehta, Rajendra H., MD, MS, Levin, Ricardo, MD, Harrington, Robert A., MD, Alexander, John H., MD, MHS
Format: Article
Language:English
Subjects:
Anesthesia & Perioperative Care
Cardiac Surgical Procedures - methods
Cardiac Surgical Procedures - mortality
cardiopulmonary bypass
Cardiopulmonary Bypass - adverse effects
Cardiopulmonary Bypass - mortality
Cardiotonic Agents - therapeutic use
Critical Care
Data Interpretation, Statistical
heart failure
Hospital Mortality
Humans
Hydrazones - therapeutic use
intensive care
meta-analysis
Perioperative Care
Postoperative Complications - mortality
Postoperative Complications - prevention & control
Publication Bias
Pyridazines - therapeutic use
Randomized Controlled Trials as Topic
Regression Analysis
Risk Assessment
statistics
Stroke Volume - physiology
Survival
Ventricular Dysfunction, Left - complications
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Summary:Objective Left ventricular systolic dysfunction is associated with increased morbidity and mortality in patients undergoing cardiac surgery. The authors performed a meta-analysis investigating the effects of levosimendan in cardiac surgery patients with and without preoperative systolic dysfunction. Design Meta-analysis of randomized controlled trials. Setting Hospital. Participants The 1,155 patients who participated in 14 randomized controlled trials of perioperative levosimendan were included. Interventions None. Measurements and Main Results PubMed, EMBASE, the Cochrane database of clinical trials, and conference proceedings were searched for clinical trials of perioperative levosimendan in patients undergoing cardiac surgery through May 1, 2012. Studies were grouped by mean ejection fraction (EF). Those with a mean EF
ISSN:1053-0770
1532-8422
DOI:10.1053/j.jvca.2013.03.027