Phosphinic acid analogues of methylaspartic and methylglutamic acids as antibacterials

DL-l-Amino-l-methyl-3-carboxypropanephosphinic acid, a bioisostere of α-methylglutamic acid, was synthesized. This compound, the corresponding α-methylaspartic acid analogue and their precursors were tested for antibacterial activity. The methylaspartic acid analogue gave a MIC of 400 and 800 µg/ml...

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Bibliographic Details
Published in:Pharmaceutical research 1985-05, Vol.2 (3), p.135-136
Main Authors: CATES, L. A, VEN-SHUN LI
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Medical sciences
Pharmacology. Drug treatments
Online Access:Get full text
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Summary:DL-l-Amino-l-methyl-3-carboxypropanephosphinic acid, a bioisostere of α-methylglutamic acid, was synthesized. This compound, the corresponding α-methylaspartic acid analogue and their precursors were tested for antibacterial activity. The methylaspartic acid analogue gave a MIC of 400 and 800 µg/ml against B. subtilis and P. aeroginosa, respectively.
ISSN:0724-8741
1573-904X
DOI:10.1023/A:1016315400847