Long-term risk of secondary skin cancers after radiation therapy for Hodgkin’s lymphoma

• Published in: Radiotherapy and oncology 2013-10, Vol.109 (1), p.140-145
• Main Authors: Daniëls, Laurien A, Krol, Augustinus D.G, Schaapveld, Michael, Putter, Hein, Jansen, Patty M, Marijt, Erik W.A, van Leeuwen, Flora E, Creutzberg, Carien L
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Cohort Studies; Female; Hematology, Oncology and Palliative Medicine; Hodgkin Disease - radiotherapy; Hodgkin’s lymphoma; Humans; Male; Middle Aged; Neoplasms, Second Primary - etiology; Radiation therapy; Radiotherapy - adverse effects; Retrospective Studies; Secondary cancers; Skin cancers; Skin Neoplasms - etiology
• ISSN: 0167-8140; 1879-0887
• DOI: 10.1016/j.radonc.2013.06.041

Abstract Purpose Survivors of Hodgkin’s lymphoma (HL) are at risk of secondary tumors. We investigated the risk of secondary skin cancers after radiotherapy compared to treatment without radiation and to an age-matched population. Material and methods We conducted a retrospective cohort study of 889 HL patients treated between 1965 and 2005. Data on secondary skin cancers and treatment fields were retrieved. Incidence rates were compared to observed rates in the Dutch population. Results 318 skin cancers were diagnosed in 86 patients, showing significantly higher risks of skin cancers, the majority being BCC. The standardized incidence ratio (SIR) of BCC in HL survivors was significantly increased (SIR 5.2, 95% CI 4.0–6.6), especially in those aged