Loading…
Long-term risk of secondary skin cancers after radiation therapy for Hodgkin’s lymphoma
Abstract Purpose Survivors of Hodgkin’s lymphoma (HL) are at risk of secondary tumors. We investigated the risk of secondary skin cancers after radiotherapy compared to treatment without radiation and to an age-matched population. Material and methods We conducted a retrospective cohort study of 889...
Saved in:
| Published in: | Radiotherapy and oncology 2013-10, Vol.109 (1), p.140-145 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c417t-d6f1a2466a3bb27ad57272fcb791806cd29ede092c14a22672034423a9cefcb23 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c417t-d6f1a2466a3bb27ad57272fcb791806cd29ede092c14a22672034423a9cefcb23 |
| container_end_page | 145 |
| container_issue | 1 |
| container_start_page | 140 |
| container_title | Radiotherapy and oncology |
| container_volume | 109 |
| creator | Daniëls, Laurien A Krol, Augustinus D.G Schaapveld, Michael Putter, Hein Jansen, Patty M Marijt, Erik W.A van Leeuwen, Flora E Creutzberg, Carien L |
| description | Abstract Purpose Survivors of Hodgkin’s lymphoma (HL) are at risk of secondary tumors. We investigated the risk of secondary skin cancers after radiotherapy compared to treatment without radiation and to an age-matched population. Material and methods We conducted a retrospective cohort study of 889 HL patients treated between 1965 and 2005. Data on secondary skin cancers and treatment fields were retrieved. Incidence rates were compared to observed rates in the Dutch population. Results 318 skin cancers were diagnosed in 86 patients, showing significantly higher risks of skin cancers, the majority being BCC. The standardized incidence ratio (SIR) of BCC in HL survivors was significantly increased (SIR 5.2, 95% CI 4.0–6.6), especially in those aged |
| doi_str_mv | 10.1016/j.radonc.2013.06.041 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1461880699</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S016781401300323X</els_id><sourcerecordid>1461880699</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-d6f1a2466a3bb27ad57272fcb791806cd29ede092c14a22672034423a9cefcb23</originalsourceid><addsrcrecordid>eNqFkb9uFDEQhy1ERC6BN0DIJc0u4z-xdxskFAWCdBIFiRQqy2fPJr7btQ97D-k6XoPX40ni0wUKGqppvvn9NN8Q8ppBy4Cpd-s2W5-iazkw0YJqQbJnZME63TfQdfo5WVRMNx2TcErOSlkDAAehX5BTLnrB2QVfkG_LFO-bGfNEcygbmgZa0KXobd7TsgmROhsd5kLtUClaO4OdQ4p0fsBst3s6pEyvk7-v7O-fvwod99P2IU32JTkZ7Fjw1dM8J7cfr24ur5vll0-fLz8sGyeZnhuvBma5VMqK1Ypr6y8013xwK92zDpTzvEeP0HPHpOVc6XqClFzY3mGluDgnb4-525y-77DMZgrF4TjaiGlXDJOKdTWp7ysqj6jLqZSMg9nmMNVLDQNzkGrW5ijVHKQaUKZKrWtvnhp2qwn936U_Fivw_ghgvfNHwGyKC1i1-ZDRzcan8L-GfwPcGGJwdtzgHss67XKsDg0zhRswXw-PPfyVCQDBxZ14BES2oDs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1461880699</pqid></control><display><type>article</type><title>Long-term risk of secondary skin cancers after radiation therapy for Hodgkin’s lymphoma</title><source>ScienceDirect Freedom Collection</source><creator>Daniëls, Laurien A ; Krol, Augustinus D.G ; Schaapveld, Michael ; Putter, Hein ; Jansen, Patty M ; Marijt, Erik W.A ; van Leeuwen, Flora E ; Creutzberg, Carien L</creator><creatorcontrib>Daniëls, Laurien A ; Krol, Augustinus D.G ; Schaapveld, Michael ; Putter, Hein ; Jansen, Patty M ; Marijt, Erik W.A ; van Leeuwen, Flora E ; Creutzberg, Carien L</creatorcontrib><description>Abstract Purpose Survivors of Hodgkin’s lymphoma (HL) are at risk of secondary tumors. We investigated the risk of secondary skin cancers after radiotherapy compared to treatment without radiation and to an age-matched population. Material and methods We conducted a retrospective cohort study of 889 HL patients treated between 1965 and 2005. Data on secondary skin cancers and treatment fields were retrieved. Incidence rates were compared to observed rates in the Dutch population. Results 318 skin cancers were diagnosed in 86 patients, showing significantly higher risks of skin cancers, the majority being BCC. The standardized incidence ratio (SIR) of BCC in HL survivors was significantly increased (SIR 5.2, 95% CI 4.0–6.6), especially in those aged <35 years at diagnosis (SIR 8.0, 95% CI 5.8–10.7). SIR increased with longer follow-up to 15.9 (95% CI 9.1–25.9) after 35 years, with 626 excess cases per 10,000 patients per year. Most (57%) skin cancers developed within the radiation fields, with significantly increased risk in patients treated with radiotherapy compared to chemotherapy alone ( p = 0·047, HR 2·75, 95% CI 1·01–7.45). Conclusion Radiotherapy for HL is associated with a strongly increased long-term risk of secondary skin cancers, both compared to the general population and to treatment with chemotherapy alone.</description><identifier>ISSN: 0167-8140</identifier><identifier>EISSN: 1879-0887</identifier><identifier>DOI: 10.1016/j.radonc.2013.06.041</identifier><identifier>PMID: 23932152</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Cohort Studies ; Female ; Hematology, Oncology and Palliative Medicine ; Hodgkin Disease - radiotherapy ; Hodgkin’s lymphoma ; Humans ; Male ; Middle Aged ; Neoplasms, Second Primary - etiology ; Radiation therapy ; Radiotherapy - adverse effects ; Retrospective Studies ; Secondary cancers ; Skin cancers ; Skin Neoplasms - etiology</subject><ispartof>Radiotherapy and oncology, 2013-10, Vol.109 (1), p.140-145</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2013 Elsevier Ireland Ltd</rights><rights>Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-d6f1a2466a3bb27ad57272fcb791806cd29ede092c14a22672034423a9cefcb23</citedby><cites>FETCH-LOGICAL-c417t-d6f1a2466a3bb27ad57272fcb791806cd29ede092c14a22672034423a9cefcb23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23932152$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Daniëls, Laurien A</creatorcontrib><creatorcontrib>Krol, Augustinus D.G</creatorcontrib><creatorcontrib>Schaapveld, Michael</creatorcontrib><creatorcontrib>Putter, Hein</creatorcontrib><creatorcontrib>Jansen, Patty M</creatorcontrib><creatorcontrib>Marijt, Erik W.A</creatorcontrib><creatorcontrib>van Leeuwen, Flora E</creatorcontrib><creatorcontrib>Creutzberg, Carien L</creatorcontrib><title>Long-term risk of secondary skin cancers after radiation therapy for Hodgkin’s lymphoma</title><title>Radiotherapy and oncology</title><addtitle>Radiother Oncol</addtitle><description>Abstract Purpose Survivors of Hodgkin’s lymphoma (HL) are at risk of secondary tumors. We investigated the risk of secondary skin cancers after radiotherapy compared to treatment without radiation and to an age-matched population. Material and methods We conducted a retrospective cohort study of 889 HL patients treated between 1965 and 2005. Data on secondary skin cancers and treatment fields were retrieved. Incidence rates were compared to observed rates in the Dutch population. Results 318 skin cancers were diagnosed in 86 patients, showing significantly higher risks of skin cancers, the majority being BCC. The standardized incidence ratio (SIR) of BCC in HL survivors was significantly increased (SIR 5.2, 95% CI 4.0–6.6), especially in those aged <35 years at diagnosis (SIR 8.0, 95% CI 5.8–10.7). SIR increased with longer follow-up to 15.9 (95% CI 9.1–25.9) after 35 years, with 626 excess cases per 10,000 patients per year. Most (57%) skin cancers developed within the radiation fields, with significantly increased risk in patients treated with radiotherapy compared to chemotherapy alone ( p = 0·047, HR 2·75, 95% CI 1·01–7.45). Conclusion Radiotherapy for HL is associated with a strongly increased long-term risk of secondary skin cancers, both compared to the general population and to treatment with chemotherapy alone.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Hodgkin Disease - radiotherapy</subject><subject>Hodgkin’s lymphoma</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasms, Second Primary - etiology</subject><subject>Radiation therapy</subject><subject>Radiotherapy - adverse effects</subject><subject>Retrospective Studies</subject><subject>Secondary cancers</subject><subject>Skin cancers</subject><subject>Skin Neoplasms - etiology</subject><issn>0167-8140</issn><issn>1879-0887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkb9uFDEQhy1ERC6BN0DIJc0u4z-xdxskFAWCdBIFiRQqy2fPJr7btQ97D-k6XoPX40ni0wUKGqppvvn9NN8Q8ppBy4Cpd-s2W5-iazkw0YJqQbJnZME63TfQdfo5WVRMNx2TcErOSlkDAAehX5BTLnrB2QVfkG_LFO-bGfNEcygbmgZa0KXobd7TsgmROhsd5kLtUClaO4OdQ4p0fsBst3s6pEyvk7-v7O-fvwod99P2IU32JTkZ7Fjw1dM8J7cfr24ur5vll0-fLz8sGyeZnhuvBma5VMqK1Ypr6y8013xwK92zDpTzvEeP0HPHpOVc6XqClFzY3mGluDgnb4-525y-77DMZgrF4TjaiGlXDJOKdTWp7ysqj6jLqZSMg9nmMNVLDQNzkGrW5ijVHKQaUKZKrWtvnhp2qwn936U_Fivw_ghgvfNHwGyKC1i1-ZDRzcan8L-GfwPcGGJwdtzgHss67XKsDg0zhRswXw-PPfyVCQDBxZ14BES2oDs</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Daniëls, Laurien A</creator><creator>Krol, Augustinus D.G</creator><creator>Schaapveld, Michael</creator><creator>Putter, Hein</creator><creator>Jansen, Patty M</creator><creator>Marijt, Erik W.A</creator><creator>van Leeuwen, Flora E</creator><creator>Creutzberg, Carien L</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131001</creationdate><title>Long-term risk of secondary skin cancers after radiation therapy for Hodgkin’s lymphoma</title><author>Daniëls, Laurien A ; Krol, Augustinus D.G ; Schaapveld, Michael ; Putter, Hein ; Jansen, Patty M ; Marijt, Erik W.A ; van Leeuwen, Flora E ; Creutzberg, Carien L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-d6f1a2466a3bb27ad57272fcb791806cd29ede092c14a22672034423a9cefcb23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Hodgkin Disease - radiotherapy</topic><topic>Hodgkin’s lymphoma</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasms, Second Primary - etiology</topic><topic>Radiation therapy</topic><topic>Radiotherapy - adverse effects</topic><topic>Retrospective Studies</topic><topic>Secondary cancers</topic><topic>Skin cancers</topic><topic>Skin Neoplasms - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Daniëls, Laurien A</creatorcontrib><creatorcontrib>Krol, Augustinus D.G</creatorcontrib><creatorcontrib>Schaapveld, Michael</creatorcontrib><creatorcontrib>Putter, Hein</creatorcontrib><creatorcontrib>Jansen, Patty M</creatorcontrib><creatorcontrib>Marijt, Erik W.A</creatorcontrib><creatorcontrib>van Leeuwen, Flora E</creatorcontrib><creatorcontrib>Creutzberg, Carien L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Radiotherapy and oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Daniëls, Laurien A</au><au>Krol, Augustinus D.G</au><au>Schaapveld, Michael</au><au>Putter, Hein</au><au>Jansen, Patty M</au><au>Marijt, Erik W.A</au><au>van Leeuwen, Flora E</au><au>Creutzberg, Carien L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term risk of secondary skin cancers after radiation therapy for Hodgkin’s lymphoma</atitle><jtitle>Radiotherapy and oncology</jtitle><addtitle>Radiother Oncol</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>109</volume><issue>1</issue><spage>140</spage><epage>145</epage><pages>140-145</pages><issn>0167-8140</issn><eissn>1879-0887</eissn><abstract>Abstract Purpose Survivors of Hodgkin’s lymphoma (HL) are at risk of secondary tumors. We investigated the risk of secondary skin cancers after radiotherapy compared to treatment without radiation and to an age-matched population. Material and methods We conducted a retrospective cohort study of 889 HL patients treated between 1965 and 2005. Data on secondary skin cancers and treatment fields were retrieved. Incidence rates were compared to observed rates in the Dutch population. Results 318 skin cancers were diagnosed in 86 patients, showing significantly higher risks of skin cancers, the majority being BCC. The standardized incidence ratio (SIR) of BCC in HL survivors was significantly increased (SIR 5.2, 95% CI 4.0–6.6), especially in those aged <35 years at diagnosis (SIR 8.0, 95% CI 5.8–10.7). SIR increased with longer follow-up to 15.9 (95% CI 9.1–25.9) after 35 years, with 626 excess cases per 10,000 patients per year. Most (57%) skin cancers developed within the radiation fields, with significantly increased risk in patients treated with radiotherapy compared to chemotherapy alone ( p = 0·047, HR 2·75, 95% CI 1·01–7.45). Conclusion Radiotherapy for HL is associated with a strongly increased long-term risk of secondary skin cancers, both compared to the general population and to treatment with chemotherapy alone.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>23932152</pmid><doi>10.1016/j.radonc.2013.06.041</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0167-8140 |
| ispartof | Radiotherapy and oncology, 2013-10, Vol.109 (1), p.140-145 |
| issn | 0167-8140 1879-0887 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1461880699 |
| source | ScienceDirect Freedom Collection |
| subjects | Adolescent Adult Aged Aged, 80 and over Child Child, Preschool Cohort Studies Female Hematology, Oncology and Palliative Medicine Hodgkin Disease - radiotherapy Hodgkin’s lymphoma Humans Male Middle Aged Neoplasms, Second Primary - etiology Radiation therapy Radiotherapy - adverse effects Retrospective Studies Secondary cancers Skin cancers Skin Neoplasms - etiology |
| title | Long-term risk of secondary skin cancers after radiation therapy for Hodgkin’s lymphoma |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T06%3A31%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Long-term%20risk%20of%20secondary%20skin%20cancers%20after%20radiation%20therapy%20for%20Hodgkin%E2%80%99s%20lymphoma&rft.jtitle=Radiotherapy%20and%20oncology&rft.au=Dani%C3%ABls,%20Laurien%20A&rft.date=2013-10-01&rft.volume=109&rft.issue=1&rft.spage=140&rft.epage=145&rft.pages=140-145&rft.issn=0167-8140&rft.eissn=1879-0887&rft_id=info:doi/10.1016/j.radonc.2013.06.041&rft_dat=%3Cproquest_cross%3E1461880699%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c417t-d6f1a2466a3bb27ad57272fcb791806cd29ede092c14a22672034423a9cefcb23%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1461880699&rft_id=info:pmid/23932152&rfr_iscdi=true |