Changes in satiety hormone concentrations and feed intake in rats in response to lactic acid bacteria

•To investigate the satiety hormone concentration in rats fed fermented milk.•To investigate feed intake.•Concentration of satiety hormones measured from blood.•Significant changes in hormone concentration detected e.g. PYY. A negative energy balance can be accomplished by reducing the caloric intak...

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Bibliographic Details
Published in:Appetite 2013-12, Vol.71, p.16-21
Main Authors: Forssten, Sofia D., Korczyńska, Marta Z., Zwijsen, Renate M.L., Noordman, Wouter H., Madetoja, Mari, Ouwehand, Arthur C.
Format: Article
Language:English
Subjects:
Animals
beverages
blood
Energy Intake
Feed intake
Fermentation
Fermented milk
Hormones
Hormones - blood
humans
hunger
ingestion
lactic acid bacteria
Lactobacillus
Male
milk
Milk - microbiology
physiological state
Probiotics - administration & dosage
Rat
Rats
Rats, Wistar
Satiation - physiology
Satiety
Satiety Response - physiology
secretion
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Summary:•To investigate the satiety hormone concentration in rats fed fermented milk.•To investigate feed intake.•Concentration of satiety hormones measured from blood.•Significant changes in hormone concentration detected e.g. PYY. A negative energy balance can be accomplished by reducing the caloric intake which results in an increased feeling of hunger. This physiological state is regulated by secretion of satiety hormones. The secretion of these hormones can be influenced by ingestion of e.g. fat. Fat, dairy beverage and synbiotic mixture have been found to have satiety-inducing effects in humans and rats. Thus, the aim of this study was to investigate the change of satiety hormone concentration in rats in response to feeding of fermented milks containing lactic acid bacteria. Two studies were conducted with Wistar rats randomly allocated into groups receiving Lactobacillus fermented (2 L. acidophilus, L. bulgaricus, L. salivarius and L. rhamnosus) milk. A single isocaloric oral dose with the test item or control was given to the rats. Blood samples were taken after dosing with the test product and the satiety hormones were measured. For the test groups, significant changes could be detected in PYY concentrations after 60min, although some groups had a significant lower feed intake. In conclusion, some probiotic Lactobacillus strains may modify satiety hormones production. However, more studies are needed to evaluate their potential of prolonging satiety.
ISSN:0195-6663
1095-8304
DOI:10.1016/j.appet.2013.06.093