Diphenyl diselenide prevents hepatic alterations induced by paraquat in rats

Highlights • We evaluated the protective effects of (PhSe)2 against hepatic injury induced by PQ. • We evaluated some parameters of oxidative stress, inflammation and hepatic damage. • The results show that (PhSe)2 has beneficial effects against PQ-induced injury. • This protection appears to involv...

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2013-11, Vol.36 (3), p.750-758
Main Authors: Costa, Michael D, de Freitas, Mayara L, Dalmolin, Laíza, Oliveira, Lia P, Fleck, Michelli A, Pagliarini, Paula, Acker, Carmine, Roman, Silvane S, Brandão, Ricardo
Format: Article
Language:English
Subjects:
Animals
Anti-inflammatory
Antioxidant
Ascorbic Acid - metabolism
Benzene Derivatives - pharmacology
Catalase - metabolism
Chemical and Drug Induced Liver Injury - pathology
Chemical and Drug Induced Liver Injury - prevention & control
Diphenyl diselenide
Emergency
Glutathione Transferase - metabolism
Herbicides - antagonists & inhibitors
Herbicides - toxicity
Lipid peroxidation
Lipid Peroxidation - drug effects
Liver - pathology
Liver Function Tests
Male
Organoselenium Compounds - pharmacology
Paraquat
Paraquat - antagonists & inhibitors
Paraquat - toxicity
Peroxidase - metabolism
Rats
Rats, Wistar
Sulfhydryl Compounds - metabolism
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Summary:Highlights • We evaluated the protective effects of (PhSe)2 against hepatic injury induced by PQ. • We evaluated some parameters of oxidative stress, inflammation and hepatic damage. • The results show that (PhSe)2 has beneficial effects against PQ-induced injury. • This protection appears to involve the antioxidant and anti-inflammatory properties.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2013.07.009