Ethanolic extract of Boswellia ovalifoliolata bark and leaf attenuates doxorubicin-induced cardiotoxicity in mice

Highlights • Alcoholic bark and leaf extract of Boswellia ovalifoliolata (BO) showed strong antioxidant activity. • These extracts of BO reduce SGPT, SGOT, LDH and CKMB activities, as well as MDA and ROS levels in doxorubicin treated animals. • These extracts of BO also increase the levels of GSH, c...

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2013-11, Vol.36 (3), p.840-849
Main Authors: Uma Mahesh, Bandari, Shrivastava, Shweta, Kuncha, Madhusudhana, Sahu, Bidya Dhar, Swamy, Challa Veerabhadra, Pragada, Rajeswara Rao, Naidu, V.G.M, Sistla, Ramakrishna
Format: Article
Language:English
Subjects:
Animals
Antibiotics, Antineoplastic - antagonists & inhibitors
Antibiotics, Antineoplastic - toxicity
Antioxidant
Antioxidants - pharmacology
Biphenyl Compounds - chemistry
Boswellia - chemistry
Boswellia ovalifoliolata
Cardioprotective
Cardiotonic Agents
Catalase - metabolism
Chromatography, Thin Layer
Doxorubicin
Doxorubicin - antagonists & inhibitors
Doxorubicin - toxicity
Emergency
Ethanol
Flavonoids - analysis
Free Radical Scavengers - pharmacology
Glutathione - metabolism
Heart Diseases - chemically induced
Heart Diseases - pathology
Heart Diseases - prevention & control
Male
Malondialdehyde - metabolism
Mice
Oxidative Stress - drug effects
Phenols - analysis
Picrates - chemistry
Plant Bark - chemistry
Plant Extracts - pharmacology
Plant Leaves - chemistry
Solvents
Thiobarbituric Acid Reactive Substances - metabolism
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Summary:Highlights • Alcoholic bark and leaf extract of Boswellia ovalifoliolata (BO) showed strong antioxidant activity. • These extracts of BO reduce SGPT, SGOT, LDH and CKMB activities, as well as MDA and ROS levels in doxorubicin treated animals. • These extracts of BO also increase the levels of GSH, catalase and SOD levels in doxorubicin treated animals. • Electrocardiogram tracing shows the protection from doxorubicin (DOX) induced ST segment alteration.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2013.07.016