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Ethanolic extract of Boswellia ovalifoliolata bark and leaf attenuates doxorubicin-induced cardiotoxicity in mice
Highlights • Alcoholic bark and leaf extract of Boswellia ovalifoliolata (BO) showed strong antioxidant activity. • These extracts of BO reduce SGPT, SGOT, LDH and CKMB activities, as well as MDA and ROS levels in doxorubicin treated animals. • These extracts of BO also increase the levels of GSH, c...
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| Published in: | Environmental toxicology and pharmacology 2013-11, Vol.36 (3), p.840-849 |
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| Main Authors: | , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c411t-4463b60987bb033c6a25440b96619220cbc2b51e37f29f85281d8f5674e4dc0a3 |
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| container_issue | 3 |
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| container_title | Environmental toxicology and pharmacology |
| container_volume | 36 |
| creator | Uma Mahesh, Bandari Shrivastava, Shweta Kuncha, Madhusudhana Sahu, Bidya Dhar Swamy, Challa Veerabhadra Pragada, Rajeswara Rao Naidu, V.G.M Sistla, Ramakrishna |
| description | Highlights • Alcoholic bark and leaf extract of Boswellia ovalifoliolata (BO) showed strong antioxidant activity. • These extracts of BO reduce SGPT, SGOT, LDH and CKMB activities, as well as MDA and ROS levels in doxorubicin treated animals. • These extracts of BO also increase the levels of GSH, catalase and SOD levels in doxorubicin treated animals. • Electrocardiogram tracing shows the protection from doxorubicin (DOX) induced ST segment alteration. |
| doi_str_mv | 10.1016/j.etap.2013.07.016 |
| format | article |
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| subjects | Animals Antibiotics, Antineoplastic - antagonists & inhibitors Antibiotics, Antineoplastic - toxicity Antioxidant Antioxidants - pharmacology Biphenyl Compounds - chemistry Boswellia - chemistry Boswellia ovalifoliolata Cardioprotective Cardiotonic Agents Catalase - metabolism Chromatography, Thin Layer Doxorubicin Doxorubicin - antagonists & inhibitors Doxorubicin - toxicity Emergency Ethanol Flavonoids - analysis Free Radical Scavengers - pharmacology Glutathione - metabolism Heart Diseases - chemically induced Heart Diseases - pathology Heart Diseases - prevention & control Male Malondialdehyde - metabolism Mice Oxidative Stress - drug effects Phenols - analysis Picrates - chemistry Plant Bark - chemistry Plant Extracts - pharmacology Plant Leaves - chemistry Solvents Thiobarbituric Acid Reactive Substances - metabolism |
| title | Ethanolic extract of Boswellia ovalifoliolata bark and leaf attenuates doxorubicin-induced cardiotoxicity in mice |
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