The effect of prophylactic treatment with Shohl's solution in children with cystinuria

Abstract Objective To investigate the effect of prophylactic treatment with Shohl's solution on the rates of stone recurrence in paediatric patients with cystinuria. Patients and methods Between June 2007 and October 2011, 185 patients aged 16 years and younger whose stones had been completely...

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Bibliographic Details
Published in:Journal of pediatric urology 2013-12, Vol.9 (6), p.1218-1222
Main Authors: Izol, Volkan, Aridogan, Ibrahim Atilla, Karsli, Onur, Deger, Mutlu, Satar, Nihat
Format: Article
Language:English
Subjects:
Adolescent
Child
Child, Preschool
Children
Citric Acid - therapeutic use
Cystinuria
Cystinuria - drug therapy
Cystinuria - epidemiology
Female
Follow-Up Studies
Humans
Hydrogen-Ion Concentration
Infant
Male
Nephrostomy, Percutaneous
Pediatrics
Potassium Citrate - therapeutic use
Recurrence
Risk Factors
Secondary Prevention
Shohl's solution
Solutions - therapeutic use
Urolithiasis
Urolithiasis - drug therapy
Urolithiasis - epidemiology
Urolithiasis - prevention & control
Urology
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Summary:Abstract Objective To investigate the effect of prophylactic treatment with Shohl's solution on the rates of stone recurrence in paediatric patients with cystinuria. Patients and methods Between June 2007 and October 2011, 185 patients aged 16 years and younger whose stones had been completely removed by percutaneous nephrolithotomy (PCNL) were assessed for metabolic risk factors. Seventeen (9%) patients with positive cyanide-nitroprusside tests (CNT) and cystine stones enrolled in this study, and a Shohl's solution was used for alkalinisation. The patients were followed up for a mean period of two years for stone recurrence. Results Of the patients, 10 (59%) were male, and 7 (41%) were female ( p  = 0.13). Twelve patients (70.5%) continued to receive medical prophylaxis regularly, whereas 5 (29.5%) patients did not. The mean pre-treatment and post-treatment urinary pH values were 5.8 ± 0.5 (5–7) and 7.5 ± 0.4 (6.5–8), respectively ( p  
ISSN:1477-5131
1873-4898
DOI:10.1016/j.jpurol.2013.05.017