Unresectable giant pancreatic neuroendocrine tumor effectively treated by high-intensity focused ultrasound: A case report and review of the literature

Abstract Patients with pancreatic neuroendocrine tumors (PNETs) diagnosed at late stage are not suitable candidates for surgery. So far, only a limited number of cases have been documented in literature about the effectiveness of HIFU, which has been more frequently reported to treat pancreatic aden...

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Bibliographic Details
Published in:Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2013-11, Vol.13 (6), p.634-638
Main Authors: Chen, Qiwen, Zhu, Xiaoyan, Chen, Qian, Wang, Kun, Meng, Zhiqiang
Format: Article
Language:English
Subjects:
Abdomen
Abdominal Pain - etiology
Abdominal Pain - therapy
Aged, 80 and over
Analgesics
Blood
Cancer therapies
Endocrinology & Metabolism
Family medical history
Gastroenterology and Hepatology
High intensity focused ultrasound
High-Intensity Focused Ultrasound Ablation - methods
Humans
Male
Medical imaging
Medical treatment
Metastasis
Neuroendocrine Tumors - diagnostic imaging
Neuroendocrine Tumors - pathology
Neuroendocrine Tumors - radiotherapy
Pain
Pain Measurement
Pancreas
Pancreatic cancer
Pancreatic Neoplasms - diagnostic imaging
Pancreatic Neoplasms - pathology
Pancreatic Neoplasms - radiotherapy
Pancreatic neuroendocrine tumor
Surgery
Treatment Outcome
Tumors
Ultrasonic imaging
Ultrasonography
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Summary:Abstract Patients with pancreatic neuroendocrine tumors (PNETs) diagnosed at late stage are not suitable candidates for surgery. So far, only a limited number of cases have been documented in literature about the effectiveness of HIFU, which has been more frequently reported to treat pancreatic adenocarcinoma rather than PNET. We report herein that a patient with a pancreatic neuroendocrine unresectable tumor was effectively treated with serial high-intensity focused ultrasound (HIFU) ablation, with no significant side effects detected. Upon evaluation, treatment results included: the tendency of tumor shrinkage, pain relief, decreased tumor marker levels, and obvious improvements in quality of life. Sustained efficacy was observed during a follow-up at 25 months with no tumor progression.
ISSN:1424-3903
1424-3911
DOI:10.1016/j.pan.2013.10.001