Study of Antitumor Activity of Antibodies to TNF-α on Walker Carcinosarcoma Model

The effect of release-active antibodies to TNF-α (Artrofoon) on the development of Walker carcinosarcoma 256 was studied in Wistar rats. Intragastric dose of this drug significantly inhibited the growth of tumor node (55% inhibition of tumor growth), but less effectively than the reference drug cycl...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2013-09, Vol.155 (5), p.673-675
Main Authors: Yurlova, E. I., Krylova, S. G., Dugina, J. L., Epstein, O. I.
Format: Article
Language:English
Subjects:
Administration, Mucosal
Animals
Antibodies
Antibodies - pharmacology
Antineoplastic Agents - pharmacology
Biomedical and Life Sciences
Biomedicine
Carcinoma 256, Walker - drug therapy
Carcinoma 256, Walker - immunology
Carcinoma 256, Walker - pathology
Cell Biology
Cyclophosphamide
Cyclophosphamide - pharmacology
Female
Gastric Mucosa - drug effects
Gastric Mucosa - immunology
Internal Medicine
Laboratory Medicine
Longevity - drug effects
Lymph Nodes - drug effects
Lymph Nodes - immunology
Lymph Nodes - pathology
Pathology
Rats
Rats, Wistar
Tumor Burden - drug effects
Tumor necrosis factor
Tumor Necrosis Factor-alpha - antagonists & inhibitors
Tumors
Viral antibodies
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Description
Summary:The effect of release-active antibodies to TNF-α (Artrofoon) on the development of Walker carcinosarcoma 256 was studied in Wistar rats. Intragastric dose of this drug significantly inhibited the growth of tumor node (55% inhibition of tumor growth), but less effectively than the reference drug cyclophosphamide (80%). The studied drug significantly prolonged animal’ lifespan (+97%) and its efficiency in this respect was comparable to that of cyclophosphamide (+96%).
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-013-2222-1