Assessment of serum leptin and resistin levels in association with the metabolic risk factors of pre- and post-menopausal rural women in South India

• Published in: Diabetes & metabolic syndrome clinical research & reviews 2013-10, Vol.7 (4), p.233-237
• Main Authors: Priya, Tanu, Chowdhury, Minakshi G, Vasanth, Karunamoorthy, Vijayakumar, Thangavel Mahalingam, Ilango, Kaliappan, Agrawal, Aruna, Dubey, Govind Prasad
• Format: Article
• Language: English
• Subjects: Adult; Biomarkers - blood; Blood Glucose - metabolism; Blood Pressure; Body Mass Index; Cross-Sectional Studies; Female; Humans; India - epidemiology; Leptin - blood; Metabolic Syndrome - blood; Metabolic Syndrome - epidemiology; Metabolic Syndrome - prevention & control; Middle Aged; Postmenopause - blood; Premenopause - blood; Resistin - blood; Risk Assessment; Rural Population; Women's Health
• ISSN: 1878-0334
• DOI: 10.1016/j.dsx.2013.06.016

Menopausal status is related with weight gain, abnormal lipid and glucose metabolism leading to metabolic syndrome susceptibility. The aim of this study is to determine circulating serum leptin and resistin levels and to correlate these levels in relationship with the metabolic factors in pre- and post-menopausal women. A cross-sectional study has been carried out for 34 subjects who were in post-menopause and 31 subjects who had regular menstruation in south Indian rural women. Anthropometric indices, blood pressure, fasting blood sugar (FBS), fasting lipid profile, fasting leptin and resistin levels were measured. In a total of 65 subjects, the mean age of pre-menopausal group was 38.65±6.21 and that of post-menopausal group was 55.32±6.32. Fasting serum leptin level was increased considerably in post-menopausal women when compared to pre-menopausal women (P=0.018). Resistin has no significant relationship with metabolic factors except Body Mass Index (BMI) in both the groups. Triglycerides and FBS were lower in pre-menopausal group when compared to post-menopausal group (P