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To be or not to be metal-free: trends and advances in coupling chemistries
Coupling reactions have been part of several extensive studies in order to develop innovative and greener protocols that can generate a wide range of compounds with applications in pharmaceuticals, agrochemicals and biologically active compounds. Metal-free couplings are an important and increasingl...
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Published in: | Organic & biomolecular chemistry 2014-01, Vol.12 (1), p.1-35 |
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creator | Arancon, Rick Arneil Sze Ki Lin, Carol Vargas, Carolina Luque, Rafael |
description | Coupling reactions have been part of several extensive studies in order to develop innovative and greener protocols that can generate a wide range of compounds with applications in pharmaceuticals, agrochemicals and biologically active compounds. Metal-free couplings are an important and increasingly trendy field that has attracted a significant deal of interest in recent years, generating a lot of controversy on the issue of whether metal free is really free. Aside from focusing on such a controversial topic itself, this contribution aims to provide a brief introduction on coupling chemistry to point out the transition of this technology from metal-catalyzed to metal-free. This is followed by a range of key selected synthetically useful metal-free processes and a brief commentary on the current debate of whether metal-free reactions are really metal-free and the required experiments for a full understanding of a metal-free coupling process.
Coupling reactions have been part of several extensive studies in order to develop innovative and greener protocols that can generate a wide range of compounds with applications in pharmaceuticals, agrochemicals and biologically active compounds. |
doi_str_mv | 10.1039/c3ob41768a |
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subjects | Catalysis Metals - chemistry Microwaves Molecular Structure Organic Chemicals - chemistry |
title | To be or not to be metal-free: trends and advances in coupling chemistries |
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