Modification of polyethersulfone hemodialysis membrane by blending citric acid grafted polyurethane and its anticoagulant activity

► Citric acid was grafted onto polyurethane, used as the anticoagulant additive. ► A new activated partial thromboplastin time method was introduced in this paper. ► The blood compatibility and cytocompatibility of the blended membrane were researched. Citric acid, a widely used anticoagulant, was g...

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Bibliographic Details
Published in:Journal of membrane science 2012-07, Vol.405-406, p.261-274
Main Authors: Li, Lulu, Cheng, Chong, Xiang, Tao, Tang, Min, Zhao, Weifeng, Sun, Shudong, Zhao, Changsheng
Format: Article
Language:English
Subjects:
adhesion
adsorption
anticoagulant activity
anticoagulants
artificial membranes
biocompatibility
blood coagulation
Blood compatibility
blood platelets
blood serum
bovine serum albumin
calcium
cattle
cell adhesion
citric acid
Citric acid grafted polyurethane
Cytocompatibility
fibrinogen
hemodialysis
ions
liver
mixing
Polyethersulfone membrane
polymerization
polyurethanes
prothrombin
thromboplastin
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Summary:► Citric acid was grafted onto polyurethane, used as the anticoagulant additive. ► A new activated partial thromboplastin time method was introduced in this paper. ► The blood compatibility and cytocompatibility of the blended membrane were researched. Citric acid, a widely used anticoagulant, was grafted onto polyurethane through a two-step solution polymerization. The novel synthesized polymer can be directly blended with polyethersulfone (PES) to prepare membranes. The modified membranes showed lower protein (bovine serum albumin, BSA; bovine serum fibrinogen, BFG) adsorption and suppressed platelet adhesion. Due to the binding of calcium ions in blood, the modified membranes effectively prolonged the activated partial thromboplastin time (APTT), prothrombin time (PT), plasma recalcification time (PRT) and the whole blood clotting time (WBCT). Furthermore, the modified membranes showed good cytocompatibility, and the surfaces promoted hepatocyte adhesion and proliferation compared to pure PES membrane. These results indicated that the surface modification by blending citric acid grafted polyurethane provided practical application of the membranes with good biocompatibility, especially the anticoagulant property; and the membranes could be used in blood purification fields, such as hemodialysis and bioaritificial liver assist devices.
ISSN:0376-7388
1873-3123
DOI:10.1016/j.memsci.2012.03.015