Predictors of Severity of Cerebral Vasospasm caused by Aneurysmal Subarachnoid Hemorrhage

Background Cerebral vasospasm is one of the leading causes of poor outcome after aneurysmal subarachnoid hemorrhage. The risk factors for the development of vasospasm have been evaluated in many clinical studies. However, it remains unclear if vasospasm severity can be predicted. The purpose of this...

Full description

Saved in:
Bibliographic Details
Published in:Journal of stroke and cerebrovascular diseases 2013-11, Vol.22 (8), p.1332-1339
Main Authors: Jabbarli, Ramazan, MD, Gläsker, Sven, MD, PhD, Weber, Johannes, MD, Taschner, Christian, MD, PhD, Olschewski, Manfred, Dipl.-Stat, Van Velthoven, Vera, MD, PhD
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
Angioplasty
Cardiovascular
cerebral vasospasm
Endpoint Determination
Female
Humans
Hydrocephalus - etiology
Hydrocephalus - physiopathology
intra-arterial papaverine
Male
Middle Aged
Neurology
predictor
Prognosis
Retrospective Studies
Risk Factors
severity
Sex Factors
subarachnoid hemorrhage
Subarachnoid Hemorrhage - complications
Subarachnoid Hemorrhage - physiopathology
Subarachnoid Hemorrhage - surgery
transcranial Doppler
Treatment Outcome
Ultrasonography
Vasospasm, Intracranial - diagnostic imaging
Vasospasm, Intracranial - etiology
Vasospasm, Intracranial - physiopathology
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Cerebral vasospasm is one of the leading causes of poor outcome after aneurysmal subarachnoid hemorrhage. The risk factors for the development of vasospasm have been evaluated in many clinical studies. However, it remains unclear if vasospasm severity can be predicted. The purpose of this study was to determine if different demographic and clinical factors that appear to be predictors of vasospasm can also prognosticate the severity of cerebral vasospasm. Methods We retrospectively analyzed consecutive patients with subarachnoid hemorrhage who underwent endovascular vasospasm treatment in a single center. In order to define predictors of vasospasm severity, we studied the demographic and clinical characteristics of these patients. Vasospasm severity was defined by cerebral angiography, transcranial Doppler ultrasound, and therapeutic response on endovascular treatment. Statistical analyses were performed to determine significant predictors. Results A total of 70 patients with vasospasm were included. Early onset of mean flow velocities >160 cm/second on transcranial Doppler ultrasound correlated with severity of angiographic vasospasm ( P = .0469) and resistance against intra-arterial papaverine ( P = .0277). Younger age (
ISSN:1052-3057
1532-8511
DOI:10.1016/j.jstrokecerebrovasdis.2013.01.006