Prospective study on burns treated with Integra®, a cellulose sponge and split thickness skin graft: comparative clinical and histological study--randomized controlled trial

The aim of this study was to compare three different methods to cover excised burn wounds in a randomized controlled trial. Fascially excised burn wounds, measuring 10 cm × 5 cm, were covered with Integra(®), split thickness skin graft (STSG), and a viscose cellulose sponge Cellonex™ in each of ten...

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Bibliographic Details
Published in:Burns : journal of the International Society for Burn Injuries 2013-12, Vol.39 (8), p.1577-1587
Main Authors: Lagus, Heli, Sarlomo-Rikala, Maarit, Böhling, Tom, Vuola, Jyrki
Format: Article
Language:English
Subjects:
Adult
Biocompatible Materials - therapeutic use
Burns - pathology
Burns - surgery
Burns - therapy
Cellulose - therapeutic use
Chondroitin Sulfates - therapeutic use
Collagen - therapeutic use
Female
Humans
Male
Middle Aged
Neovascularization, Physiologic
Prospective Studies
Skin Transplantation - methods
Surgical Sponges
Young Adult
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Summary:The aim of this study was to compare three different methods to cover excised burn wounds in a randomized controlled trial. Fascially excised burn wounds, measuring 10 cm × 5 cm, were covered with Integra(®), split thickness skin graft (STSG), and a viscose cellulose sponge Cellonex™ in each of ten adult patients. Integra(®) and Cellonex™ treated areas were covered with thin STSG on day 14. Biopsies were taken 3, 7, 14, and 21 days, 3 months, and 12 months after surgery, and samples were subjected to a range of immunohistochemical stains, in addition to hematoxylin and eosin (HE). Scar assessment was performed 3 and 12 months post-operatively with the Vancouver Scar Scale (VSS). Inflammation was not substantial in any of the study areas, but Cellonex™ had the most neutrophils, histiocytes, and lymphocytes with significant differences on days 7 and 14. Complete vascularization of Integra(®) seemed to occur later compared to the other materials. STSG had the most myofibroblasts on day 14 (p = 0.012). In VSS the quality of the scar improved in all materials from 3 to 12 months. The final results for all treatments after 12 months demonstrate equal clinical appearance, as well as histological and immunohistochemical findings.
ISSN:1879-1409
DOI:10.1016/j.burns.2013.04.023