Subcutaneous and gonadal adipose tissue transcriptome differences in lean and obese female dogs

Summary Canine obesity leads to shortened life span and increased disease incidence. Adipose tissue depots are known to have unique metabolic and gene expression profiles in rodents and humans, but few comparisons of depot gene expression have been performed in the dog. Using microarray technology,...

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Bibliographic Details
Published in:Animal genetics 2013-12, Vol.44 (6), p.728-735
Main Authors: Grant, Ryan W., Vester Boler, Brittany M., Ridge, Tonya K., Graves, Thomas K., Swanson, Kelly S.
Format: Article
Language:English
Subjects:
adipose depot
Animals
canine
Dog Diseases - metabolism
Dogs
Female
gene expression
Gene Expression Profiling - veterinary
Gonads - cytology
Gonads - metabolism
Linear Models
Microarray Analysis - veterinary
Obesity - metabolism
Obesity - veterinary
Real-Time Polymerase Chain Reaction - veterinary
Reverse Transcriptase Polymerase Chain Reaction - veterinary
Subcutaneous Fat - metabolism
Transcriptome - genetics
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Summary:Summary Canine obesity leads to shortened life span and increased disease incidence. Adipose tissue depots are known to have unique metabolic and gene expression profiles in rodents and humans, but few comparisons of depot gene expression have been performed in the dog. Using microarray technology, our objective was to identify differentially expressed genes and enriched functional pathways between subcutaneous and gonadal adipose of lean and obese dogs to better understand the pathogenesis of obesity in the dog. Because no depot × body weight status interactions were identified in the microarray data, depot differences were the primary focus. A total of 946 and 703 transcripts were differentially expressed (FDR P 
ISSN:0268-9146
1365-2052
DOI:10.1111/age.12060