Estimation of transmembrane potential of thymic lymphocytes during dexamethasone-induced apoptosis

The use of potential-sensitive fluorescent probes allowed us to estimate transmembrane potentials of the plasma ([delta]Φ^sub p^) and mitochondrial ([delta]Φ^sub m^) membranes of rat thymocytes, which were -58±3 mV and -169±7 mV, respectively. Dexamethasone-induced apoptosis led to a significant dec...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 1999-01, Vol.127 (1), p.106-109
Main Authors: Dukhanin, A S, Patrashev, D V
Format: Article
Language:English
Subjects:
Apoptosis
Materials science
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Summary:The use of potential-sensitive fluorescent probes allowed us to estimate transmembrane potentials of the plasma ([delta]Φ^sub p^) and mitochondrial ([delta]Φ^sub m^) membranes of rat thymocytes, which were -58±3 mV and -169±7 mV, respectively. Dexamethasone-induced apoptosis led to a significant decrease in [delta]Φ^sub p^ (by 55%) and [delta]Φ^sub m^ (by 17%). This effects of dexamethasone was dose- and time-dependent. Changes in [delta]Φ^sub m^ were greater and preceded those in [delta]Φ^sub p^.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02432815