Normal and Premature Rupture of Fetal Membranes at Term Delivery Differ in Regional Chemotactic Activity and Related Chemokine/Cytokine Production

A gradient of immunological mediators exists in the fetal membranes from the periplacental zone (PZ) to the rupture zone (RZ) at term delivery (rupture of fetal membranes [ROM]). However, it is unknown if this gradient is different in premature rupture of these tissues (premature rupture of fetal me...

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Published in:Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2013-03, Vol.20 (3), p.276-284
Main Authors: Gomez-Lopez, Nardhy, Hernandez-Santiago, Susana, Lobb, Andrew P., Olson, David M., Vadillo-Ortega, Felipe
Format: Article
Language:English
Subjects:
Chemokines
Chemokines - metabolism
Chemokines - secretion
Chemotaxis - physiology
Cytokines - metabolism
Cytokines - secretion
Delivery, Obstetric
Embryology
Extraembryonic Membranes - metabolism
Extraembryonic Membranes - secretion
Female
Fetal Membranes, Premature Rupture - diagnosis
Fetal Membranes, Premature Rupture - metabolism
Humans
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Organ Culture Techniques
Original Article
Pregnancy
Reproductive Medicine
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Summary:A gradient of immunological mediators exists in the fetal membranes from the periplacental zone (PZ) to the rupture zone (RZ) at term delivery (rupture of fetal membranes [ROM]). However, it is unknown if this gradient is different in premature rupture of these tissues (premature rupture of fetal membranes [PROM]). We therefore analyzed leukocyte chemotactic activity and chemokine/cytokine production in fetal membrane zones in ROM and PROM. In ROM, leukocyte chemotactic activity increased from the PZ to the RZ; however, this did not occur in PROM. This was due to consistently elevated leukocyte chemotactic activity in PROM compared to ROM tissues. In the RZ, ROM was characterized by increased T-cell attraction and high levels of chemokine (C-X-C motif) ligand 8 (CXCL-8)/interleukin 8, and PROM by increased granulocyte attraction and high levels of granulocyte-macrophage colony-stimulating factor and CXCL-10/interferon gamma-induced protein 10. We conclude that normal and premature rupture of fetal membranes differ in regional chemotactic activity and related chemokine/cytokine production, which may represent evidence for differential mechanisms of rupture at term delivery.
ISSN:1933-7191
1933-7205
DOI:10.1177/1933719112452473