Obesity, adipokines and hepatocellular carcinoma

Obesity is rapidly becoming pandemic and is associated with increased carcinogenesis, especially hepatocellular carcinoma (HCC). Adipose tissue is considered as an endocrine organ because of its capacity to secrete a variety of adipokines, such as leptin, adiponectin and resistin. Recently, adipokin...

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Bibliographic Details
Published in:International journal of cancer 2013-10, Vol.133 (8), p.1776-1783
Main Authors: Duan, Xiao‐Feng, Tang, Peng, Li, Qiang, Yu, Zhen‐Tao
Format: Article
Language:English
Subjects:
adipokine
adiponectin
Adiponectin - metabolism
Adipose Tissue - metabolism
Biological and medical sciences
Cancer
Carcinoma, Hepatocellular - etiology
Carcinoma, Hepatocellular - physiopathology
Cell Transformation, Neoplastic
Disease Progression
Gastroenterology. Liver. Pancreas. Abdomen
hepatocellular carcinoma
Humans
leptin
Leptin - metabolism
Liver cancer
Liver Cirrhosis
Liver Neoplasms - etiology
Liver Neoplasms - physiopathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical research
Medical sciences
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Obesity
Obesity - metabolism
Resistin - metabolism
Tumors
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Summary:Obesity is rapidly becoming pandemic and is associated with increased carcinogenesis, especially hepatocellular carcinoma (HCC). Adipose tissue is considered as an endocrine organ because of its capacity to secrete a variety of adipokines, such as leptin, adiponectin and resistin. Recently, adipokines have been demonstrated to be associated with kinds of chronic liver diseases including fibrosis, cirrhosis and carcinogenesis. Direct evidence is accumulating rapidly supporting the inhibitory and/or activating role of adipokines in the process of carcinogenesis and progression of human HCC. This review aims to provide important insight into the potential mechanisms of adipokines in the development of HCC.
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.28105