Toll-Like Receptor Induced Pro-Interleukin-1 beta and Interleukin-6 in Monocytes Are Lower in Healthy Infants Compared to Adults: e78018

Infants have long been known to have higher infectious diseases morbidity and mortality and suboptimal vaccination responses compared to older children and adults. A variety of differences in innate and adaptive immune responses have been described between these two groups. We compared Toll-like rec...

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Published in:PloS one 2013-10, Vol.8 (10)
Main Authors: Libraty, Daniel H, Zhang, Lei, Woda, Marcia, Acosta, Luz P, Obcena, AnaMae, Brion, Job D, Capeding, Rosario Z
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Woda, Marcia
Acosta, Luz P
Obcena, AnaMae
Brion, Job D
Capeding, Rosario Z
description Infants have long been known to have higher infectious diseases morbidity and mortality and suboptimal vaccination responses compared to older children and adults. A variety of differences in innate and adaptive immune responses have been described between these two groups. We compared Toll-like receptor (TLR)-induced production of pro-interleukin (IL)-1 beta , IL-6, and tumor necrosis factor (TNF)- alpha between 2-month-old infants and adults. TLR 7/8-induced production of pro-IL-1 beta and IL-6 in monocytes was lower in 2-month-old infants compared to adults. There was no difference in TLR 7/8-induced production of TNF- alpha . Lower TLR-induced production of pro-IL-1 beta and IL-6 in innate immune cells during early infancy likely contributes to suboptimal vaccine responses and infectious diseases susceptibility.
doi_str_mv 10.1371/journal.pone.0078018
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title Toll-Like Receptor Induced Pro-Interleukin-1 beta and Interleukin-6 in Monocytes Are Lower in Healthy Infants Compared to Adults: e78018
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