Characterization of benzodiazepine receptors of human lymphocytes

It is demonstrated that benzodiazepine binding sites on human peripheral blood lymphocytes are the peripheral type receptors. The binding sites for the selective agonist^sup 3^H-Ro 5-4864, but not for the antagonist^sup 3^H-PK 11195, are completely inactivated by freezing-thawing of lymphocytes. The...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 1998-10, Vol.126 (4), p.1003-1005
Main Authors: Lesnichuk, S. A., Katukov, V. Yu, Porodenko, N. V., Severin, E. S.
Format: Article
Language:English
Subjects:
Benzodiazepine
Binding sites
Lymphocytes
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Summary:It is demonstrated that benzodiazepine binding sites on human peripheral blood lymphocytes are the peripheral type receptors. The binding sites for the selective agonist^sup 3^H-Ro 5-4864, but not for the antagonist^sup 3^H-PK 11195, are completely inactivated by freezing-thawing of lymphocytes. The binding of^sup 3^H-Ro 5-4864 to intact lymphocytes is activated by GABA and (+)baclofen. It is shown that the selective ligands Ro 5-4864 and PK 11195 bind to different subtypes of benzodiazepine receptors on human peripheral blood lymphocytes.[PUBLICATION ABSTRACT]
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02447304